Cocrystal and its Application in the Field of Active Pharmaceutical Ingredients and Food Ingredients
| Autor: | Chuang Xie, Weiyi Su, Nannan Guo, Yajing Lou, Hongxun Hao, Haijiao Lu, Na Wang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pharmacology
Active ingredient Chemistry Food Ingredients Clinical performance Biological Availability Nanotechnology 02 engineering and technology 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy Cocrystal Dosage form Bioavailability 03 medical and health sciences 0302 clinical medicine Pharmaceutical Preparations Solubility Drug Discovery Crystallization 0210 nano-technology Dissolution |
| Zdroj: | Current Pharmaceutical Design. 24:2339-2348 |
| ISSN: | 1381-6128 |
| DOI: | 10.2174/1381612824666180522102732 |
| Popis: | Background: The development of solid drug dosage form and food ingredients is constrained by their low solubility, low dissolution, low bioavailability and poor physicochemical properties. Formation of cocrystal is a novel and promising method to enhance and improve the properties of materials without breaking the covalent bonds. Methods: The goal of this review is to summarize the cocrystals and their applications in the field of Active Pharmaceutical Ingredients (APIs) and food ingredients (AFIs), mainly on the effective improvements of APIs’ and AFIs’ pharmacokinetic, physicochemical and mechanical properties by the formation of cocrystals. Results: After years of research and development on cocrystals in the area of pharmaceutical and food industries, significant progress has been made. Formation of cocrystal is an efficient method for improving the solubility, dissolution rate, permeability and in vivo bioavailability of APIs and AFIs, as well as for enhancing stability and mechanical properties. Conclusion: Cocrystals exhibit complex structures which can conspicuously affect the physical and chemical properties of original substance, with good clinical performance and outstanding stability during processing and storage. |
| Databáze: | OpenAIRE |
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