Altered dendritic morphology in dorsolateral prefrontal cortex of nonhuman primates prenatally exposed to maternal immune activation
| Autor: | Kari L. Hanson, Ruth K. Weir, Ana-Maria Iosif, Judy Van de Water, Cameron S. Carter, A. Kimberley McAllister, Melissa D. Bauman, Cynthia M. Schumann |
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| Rok vydání: | 2023 |
| Předmět: |
Male
Autism Neuroimmunology Immunology Prefrontal Cortex NHP Reproductive health and childbirth Basic Behavioral and Social Science Article Behavioral Neuroscience Dorsolateral Prefrontal Cortex Pregnancy Behavioral and Social Science Golgi Maternal immune activation Animals Humans Psychology Animal model Pediatric Behavior Neurology & Neurosurgery Animal Endocrine and Autonomic Systems Mental Disorders Neurosciences Brain Brain Disorders Neuroanatomy Poly I-C Poly IC Mental Health Maternal Exposure Prenatal Exposure Delayed Effects Disease Models Neurological Schizophrenia Female |
| Zdroj: | Brain Behav Immun |
| ISSN: | 0889-1591 |
| DOI: | 10.1016/j.bbi.2023.01.003 |
| Popis: | Women who contract a viral or bacterial infection during pregnancy have an increased risk of giving birth to a child with a neurodevelopmental or psychiatric disorder. The effects of maternal infection are likely mediated by the maternal immune response, as preclinical animal models have confirmed that maternal immune activation (MIA) leads to long lasting changes in offspring brain and behavior development. The present study sought to determine the impact of MIA-exposure during the first or second trimester on neuronal morphology in dorsolateral prefrontal cortex (DLPFC) and hippocampus from brain tissue obtained from MIA-exposed and control male rhesus monkey (Macaca mulatta) during late adolescence. MIA-exposed offspring display increased neuronal dendritic branching in pyramidal cells in DLPFC infra- and supragranular layers relative to controls, with no significant differences observed between offspring exposed to maternal infection in the first and second trimester. In addition, the diameter of apical dendrites in DLPFC infragranular layer is significantly decreased in MIA-exposed offspring relative to controls, irrespective of trimester exposure. In contrast, alterations in hippocampal neuronal morphology of MIA-exposed offspring were not evident. These findings demonstrate that a maternal immune challenge during pregnancy has long-term consequences for primate offspring dendritic structure, selectively in a brain region vital for socioemotional and cognitive development. |
| Databáze: | OpenAIRE |
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