Can efficiency of the photosensitizer be predicted by its photostability in solution?
| Autor: | Priscila Fernanda Campos de Menezes, Vanderlei Salvador Bagnato, Juliana Carvalho Ferreira, Claudio Sibata, Ron R. Allison, O. Castro e Silva, Sérgio Zucoloto |
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| Rok vydání: | 2009 |
| Předmět: |
Hematoporphyrin
CITOTOXINAS business.industry Chemistry medicine.medical_treatment Photodynamic therapy Condensed Matter Physics Photochemistry Industrial and Manufacturing Engineering Atomic and Molecular Physics and Optics chemistry.chemical_compound Threshold dose Optics medicine Dosimetry Photosensitizer Photodegradation business Instrumentation |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1555-6611 1054-660X |
| Popis: | We have investigated a possible correlation between the photostability and photodynamic efficacy for different photosensitizers; hematoporphyrin derivatives and chlorines. To perform such analysis, we combined the depth of necrosis (d nec) measurement, expressed by the light threshold dose and a photodegradation parameter, measured from investigation of photosensitizer degradation in solution. The d nec analysis allows us to determine the light threshold dose and compare its value with the existent results in the literature. The use of simple models to understand basic features of Photodynamic Therapy (PDT) may contribute to the solid establishment of dosimetry in PDT, enhancing its use in the clinical management of cancers and others lesions. Using hematoporphyrin derivatives and chlorines photosensitizers we investigated their properties related to the photodegradation in solution and the light threshold dose (D th) in rat livers. |
| Databáze: | OpenAIRE |
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