Aortic Wall Extracellular Matrix Proteins Correlate with Syntax Score in Patients Undergoing Coronary Artery Bypass Surgery
| Autor: | Chuen N. Lee, Chin C. Woo, Vitaly Sorokin, Mikael Hartman, Lay Wai Khin, Terri Chiong, Esther Sok Hwee Cheow, Siu Kwan Sze, Xiao Y. Lin |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
EMACCE 030204 cardiovascular system & hematology Article Extracellular matrix 03 medical and health sciences Coronary artery bypass surgery 0302 clinical medicine Text mining Internal medicine Medicine Syntax 030212 general & internal medicine Stroke biology business.industry medicine.disease humanities Elastin Surgery Cohort Cardiology biology.protein Biomarker (medicine) Immunohistochemistry Collagen Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Open Cardiovascular Medicine Journal |
| ISSN: | 1874-1924 |
| DOI: | 10.2174/1874192401610010048 |
| Popis: | Aims: The SYNTAX score correlate with major cardiovascular events post-revascularization, although the histopathological basis is unclear. We aim to evaluate the association between syntax score and extracellular matrix histological characteristics of aortic punch tissue obtained during coronary artery bypass surgery (CABG). This analysis compares coronary artery bypass surgery patients with High and Low syntax score which were followed up for one year period. Methods and Results: Patients with High (score ≥ 33, (n=77)) and Low Syntax Scores (score ≤ 22, (n=71)) undergoing elective CABG were recruited prospectively. Baseline clinical characteristics and surgical risks were well matched. At 1 year, EMACCE (Sum of cardiovascular death, stroke, congestive cardiac failure, and limb, gut and myocardial ischemia) was significantly elevated in the High syntax group (P=0.022). Mass spectrometry (MS)-based quantitative iTRAQ proteomic results validated on independent cohort by immunohistochemistry (IHC) revealed that the High syntax group had significantly upraised Collagen I (PP Conclusion: This study shows that aortic extracellular matrix (ECM) differ between High and Low syntax groups with up-regulation of Collagen I and Elastin level in High Syntax Score group. This identifies aortic punches collected during CABG as another biomarker source related with atherosclerosis severity and possible clinical outcome. |
| Databáze: | OpenAIRE |
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