Cortical morphometry and neural dysfunction in Huntington’s disease: a review
| Autor: | Alex Fornito, Govinda Poudel, Rosita Shishegar, Brendan Tan, Nellie Georgiou-Karistianis |
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| Rok vydání: | 2020 |
| Předmět: |
neuronal dysfunction
Disease 03 medical and health sciences 0302 clinical medicine Atrophy Huntington's disease Neuroimaging medicine Humans 030212 general & internal medicine neuroimaging medicine.diagnostic_test business.industry Disease progression Brain Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Huntington Disease cortical morphometry Neurology Disease Progression Biomarker (medicine) Neurology (clinical) network spread hypothesis business Patient stratification Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Neurology. 28:1406-1419 |
| ISSN: | 1468-1331 1351-5101 |
| DOI: | 10.1111/ene.14648 |
| Popis: | Numerous neuroimaging techniques have been used to identify biomarkers of disease progression in Huntington's disease (HD). To date, the earliest and most sensitive of these is caudate volume; however, it is becoming increasingly evident that numerous changes to cortical structures, and their interconnected networks, occur throughout the course of the disease. The mechanisms by which atrophy spreads from the caudate to these cortical regions remains unknown. In this review, the neuroimaging literature specific to T1-weighted and diffusion-weighted magnetic resonance imaging is summarized and new strategies for the investigation of cortical morphometry and the network spread of degeneration in HD are proposed. This new avenue of research may enable further characterization of disease pathology and could add to a suite of biomarker/s of disease progression for patient stratification that will help guide future clinical trials. |
| Databáze: | OpenAIRE |
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