Intravenous versus oral iron for treatment of iron deficiency in non-hemodialysis-dependent patients with chronic kidney disease
| Autor: | Anne Marie Liles |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Anemia medicine.medical_treatment Iron Population Administration Oral Gastroenterology Renal Dialysis Internal medicine medicine Humans education Randomized Controlled Trials as Topic Pharmacology education.field_of_study biology Anemia Iron-Deficiency Transferrin saturation business.industry Health Policy Iron deficiency Iron Deficiencies medicine.disease Surgery Ferritin Injections Intravenous biology.protein Kidney Failure Chronic Hemoglobin Hemodialysis business Kidney disease |
| Zdroj: | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 69(14) |
| ISSN: | 1535-2900 |
| Popis: | Purpose The evidence evaluating the efficacy of i.v. versus oral iron for the treatment of iron deficiency in non-hemodialysis-dependent patients with chronic kidney disease (CKD) is reviewed. Summary Although erythropoiesis-stimulating agents (ESAs) are the mainstay of anemia treatment, concomitant iron supplementation is often required. Patients with CKD are at risk for developing iron deficiency due to frequent blood testing, decreased dietary intake, inflammation, decreased gastrointestinal absorption, the use of phosphate binders, hemodialysis, and treatment with ESAs. Seven randomized, controlled trials compared i.v. and oral iron in this population, six in patients treated with ESAs and one in patients not receiving ESAs. Two studies found no difference between i.v. and oral iron. An additional study found the two formulations to be equivalent when evaluating ESA dosage requirements. All studies found i.v. iron to be superior in increasing ferritin and transferrin saturation (TSAT) levels. Five of the studies compared baseline laboratory values for patients treated with i.v. and oral iron; all of these found oral iron to significantly increase hemoglobin, ferritin, or TSAT levels. Only one trial found a significant decrease from baseline in ferritin and TSAT for oral iron. Interpretation of the results of these studies is limited by several factors, the most significant of which is a short study duration, ranging from 21 days to six months. Conclusion Published evidence does not support the use of i.v. iron over oral iron to treat deficiencies in non-hemodialysis-dependent patients with CKD. While studies found that i.v. iron significantly increased serum levels of ferritin and TSAT, hemoglobin levels were not consistently raised. |
| Databáze: | OpenAIRE |
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