The antiplasmodial activity of spermine alkaloids isolated from Albizia gummifera
| Autor: | W Lwande, G.M. Mungai, F. Omlin, C.N. Muthaura, Festus M. Tolo, S.A. Omar, Francis W. Muregi, W.M. Kofi-Tsekpo, Peter Mwitari, FW Iraqi, Wolfgang Kraus, Ahmed Hassanali, G.M. Rukunga, John I. Githure |
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| Rok vydání: | 2007 |
| Předmět: |
endocrine system
Plasmodium berghei Plasmodium falciparum Spermine Albizzia Pharmacognosy Plant Roots complex mixtures Antimalarials Inhibitory Concentration 50 Mice chemistry.chemical_compound Alkaloids Parasitic Sensitivity Tests In vivo parasitic diseases Drug Discovery Animals heterocyclic compounds Malaria Falciparum Pharmacology Mice Inbred BALB C Plant Stems biology Traditional medicine Plant Extracts organic chemicals Alkaloid General Medicine biology.organism_classification Albizia chemistry Biochemistry Plant Bark Female Polyamine Phytotherapy |
| Zdroj: | Fitoterapia. 78:455-459 |
| ISSN: | 0367-326X |
| DOI: | 10.1016/j.fitote.2007.02.012 |
| Popis: | In the present study the methanolic extract of Albizia gummifera was fractionated into various fractions. These fractions were tested against choroquine sensitive (NF54) and resistant (ENT30) strains of Plasmodium falciparum . All other fractions apart from the alkaloidal fraction showed low activity with IC 50 above 3 μg/ml. The alkaloidal fraction exhibited strong activity against NF54 and ENT30 with IC 50 of 0.16 ± 0.05 and 0.99 ± 0.06 μg/ml, respectively. Five known spermine alkaloids were isolated from the alkaloidal fraction. These alkaloids exhibited activities against NF54 and ENT30 with IC 50 ranging from 0.09 ± 0.02 to 0.91 ± 0.10 μg/ml. Four of the alkaloids were further evaluated for in vivo activity against rodent malaria parasite Plasmodium berghei . The alkaloids showed percentage chemosuppression of parasitaemia in mice ranging from 43 to 72%. The use of the extracts A. gummifera for treatment of malaria in traditional medicine seems to have a scientific basis. |
| Databáze: | OpenAIRE |
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