The novel myokine irisin: clinical implications and potential role as a biomarker for sarcopenia in postmenopausal women
| Autor: | Sung Kil Lim, Hyungseon Yeom, Hye Sun Park, Dongdong Zhang, Hyun Chang Kim |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Sarcopenia
medicine.medical_specialty Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Endocrinology Bone Density Internal medicine Diabetes mellitus Myokine medicine Humans Quantitative computed tomography Muscle Skeletal Aged Bone mineral Hand Strength medicine.diagnostic_test business.industry Confounding medicine.disease Confidence interval Fibronectins Postmenopause 030220 oncology & carcinogenesis Body Composition Biomarker (medicine) Female Tomography X-Ray Computed business Biomarkers |
| Zdroj: | Endocrine. 64:341-348 |
| ISSN: | 1559-0100 1355-008X |
| DOI: | 10.1007/s12020-018-1814-y |
| Popis: | To clarify the association of circulating irisin with muscle, liver and bone, and to evaluate irisin as a biomarker for sarcopenia in postmenopausal women. Quadriceps cross-sectional area (QcCSA), bone mineral density (BMD), liver attenuation (measured in Hounsfield units (HU)) were assessed using quantitative computed tomography in 153 postmenopausal women, mean age of 72.20 ± 5.96 years. Muscle strength and physical performance were evaluated by handgrip test and short physical performance battery, respectively. Serum irisin was measured by an enzyme-linked immunosorbent assay kit. In addition, 147 young women were recruited as a reference group to define cut-off values for sarcopenia. Circulating irisin was positively correlated with QcCSA/body weight (BW) and liver HU even after adjusting for multiple covariates, and the serum level was significantly lower in the sarcopenia group (QcCSA/BW |
| Databáze: | OpenAIRE |
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