Role of glucagon in maintenance of euglycemia in fed and fasted rats
| Autor: | J. Warberg, Christian L. Brand, I. Svendsen, Jens J. Holst, U. Knigge, J S Kristensen, Peer Nobert Jørgensen |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Blood Glucose
Male Adrenergic Antagonists medicine.medical_specialty Physiology Endocrinology Diabetes and Metabolism medicine.medical_treatment Glucagon Rats Sprague-Dawley Eating Catecholamines Physiology (medical) Internal medicine medicine Animals Insulin Phentolamine Pancreatic hormone business.industry Temperature Antibodies Monoclonal Nutritional status Fasting Metabolism Propranolol Rats Endocrinology Immunologic Techniques Catecholamine business medicine.drug |
| Zdroj: | CIÊNCIAVITAE Europe PubMed Central |
| ISSN: | 1522-1555 0193-1849 |
| DOI: | 10.1152/ajpendo.1995.269.3.e469 |
| Popis: | The role of glucagon in the regulation of blood glucose in fed and fasted anesthetized rats was studied by injecting intravenously 4 ml/kg of a high-capacity (40 nmol/ml) high-affinity (0.6 x 10(11) mol/l) monoclonal glucagon antibody. Blood glucose was lowered by the antibody by 2 mmol/l in fed rats but remained unchanged in 10- and 48-h-fasted rats. Antibody injection significantly reduced plasma insulin in both fed and 10-h-fasted rats. In 10-h-fasted rats, propranolol injection decreased blood glucose by 0.6 mmol/l, and combined with antibody administration, a decrease by 1.1 mmol/l was observed. Blood glucose was never < 3.3 mmol/l. Thus glucagon is partly responsible for maintenance of euglycemia in fed rats, whereas during fasting it plays a limited role. However, immunoneutralization of glucagon reduces insulin secretion irrespective of blood glucose. Additional mechanisms seem to be responsible for the maintenance of blood glucose in the fasting state when glucagon and the sympathoadrenergic system are blocked. |
| Databáze: | OpenAIRE |
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