Decreased lymphocyte dopamine transporter in romantic lovers
Autor: | Grazia Rutigliano, Federico Mucci, Liliana Dell'Osso, Armando Piccinni, Stefano Baroni, Gino Giannaccini, Mario Catena-Dell'Osso, Gabriele Massimetti, Donatella Marazziti |
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Rok vydání: | 2016 |
Předmět: |
Adult
Male medicine.medical_specialty Synaptic cleft Lymphocyte 030226 pharmacology & pharmacy [3H]-Dopamine reuptake Reuptake 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Dopamine 428 binding romantic love Internal medicine medicine Humans Lymphocytes [3H]-WIN 35 Neurotransmitter dopamine transporter Dopamine transporter [3H]-Dopamine reuptake [3H]-WIN 35 428 binding romantic love dopamine dopamine transporter resting lymphocytes Dopamine Plasma Membrane Transport Proteins biology business.industry Romance Love Endocrinology medicine.anatomical_structure chemistry Psychiatry and Mental Health biology.protein resting lymphocytes Female Neurology (clinical) dopamine Early phase business 030217 neurology & neurosurgery medicine.drug |
Zdroj: | CNS spectrums. 22(3) |
ISSN: | 1092-8529 |
Popis: | ObjectiveThe role of dopamine (DA) in romantic love is suggested by different evidence and is supported by the findings of some brain imaging studies. The DA transporter (DAT) is a key structure in regulating the concentration of the neurotransmitter in the synaptic cleft. Given the presence of DAT in blood cells, the present study aimed to explore it in resting lymphocytes of 30 healthy subjects of both sexes in the early stage of romantic love (no longer than 6 months), as compared with 30 subjects involved in a long-lasting relationship.MethodsAll subjects had no physical or psychiatric illness. The DAT was measured by means of the [3H]-WIN 35,428 binding and the [3H]-DA reuptake to resting lymphocytes membranes. Romantic love was assessed by a specific questionnaire developed by us.ResultsThe results showed that the subjects in the early phase of romantic love had a global alteration of the lymphocyte DAT involving both a decreased number of proteins (Bmax) and a reduced functionality (Vmax).ConclusionsTaken together, these findings would indicate the presence of increased levels of DA in romantic love that, if paralleled by similar concentrations in the brain, would explain some peculiar features of this human feeling. |
Databáze: | OpenAIRE |
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