Characteristic antitumor activity of cytarabine ocfosfate against human colorectal adenocarcinoma xenografts in nude mice
| Autor: | Hisao Ekimoto, Akira Sato, Kunihiko Koga, Eri Iizuka, Mineaki Okada |
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| Rok vydání: | 1995 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Lung Neoplasms Cyclophosphamide Transplantation Heterologous Pirarubicin Drug Evaluation Preclinical Mice Nude Antineoplastic Agents Adenocarcinoma Toxicology Drug Administration Schedule Mice Stomach Neoplasms Cytidine Monophosphate medicine Animals Humans Pharmacology (medical) Doxorubicin Pharmacology Cisplatin Lung Arabinonucleotides business.industry Mitomycin C medicine.disease digestive system diseases medicine.anatomical_structure Oncology Fluorouracil Cancer research Colorectal Neoplasms business medicine.drug |
| Zdroj: | Cancer Chemotherapy and Pharmacology. 36:459-462 |
| ISSN: | 1432-0843 0344-5704 |
| DOI: | 10.1007/bf00685794 |
| Popis: | The antitumor activity of cytarabine ocfosfate (SPAC) was tested against human colorectal, gastric and lung adenocarcinoma xenografts in nude mice in comparison with the activities of various antitumor drugs used clinically. SPAC showed higher therapeutic efficacy against human colorectal adenocarcinoma xenografts than against human gastric and lung adenocarcinoma xenografts. SPAC was effective against three of four human colorectal adenocarcinoma xenografts, with efficacy higher than that of 1-beta-D-arabinofuranosylcytosine, fluorouracil, cisplatin, doxorubicin, pirarubicin and vindesine sulfate, but lower than that of mitomycin C and cyclophosphamide. These results indicate that SPAC may be useful for induction and/or postoperative chemotherapy against colorectal adenocarcinomas. |
| Databáze: | OpenAIRE |
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