Mindfulness-based interventions modulate structural network strength in patients with opioid dependence
| Autor: | Robert Christian Wolf, Maha Wasfi, Miriam Wittemann, Nadine D. Wolf, Ahmed Wahba, Reham Fahmy, Rania Mamdouh, Fabio Sambataro, Dusan Hirjak, Kareem Moussa, Katharina M. Kubera |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Impulsivity Mindfulness Psychological intervention Medicine (miscellaneous) Toxicology 050105 experimental psychology Frontal cortex MRI Opiates Source-based morphometry Striatum Clinical Psychology Psychiatry and Mental Health 03 medical and health sciences 0302 clinical medicine medicine Humans 0501 psychology and cognitive sciences In patient Mindfulness based interventions Brain Mapping Cognitive Behavioral Therapy business.industry 05 social sciences Brain Opioid-Related Disorders Magnetic Resonance Imaging Opioid Cortical network Female Nerve Net Substance use medicine.symptom business 030217 neurology & neurosurgery medicine.drug Clinical psychology |
| Popis: | Mindfulness-based interventions (MBI) are increasingly used in the treatment of patients with mental disorders, in particular in individuals presenting with affective disorders or in patients exhibiting abnormal levels of impulsive behavior. MBI have been also offered to patients with substance use disorders, where such treatment options may yield considerable clinical effects. Neural effects associated with MBI have been increasingly acknowledged, but is unknown whether MBI exert specific effects on brain structure in patients with substance use disorders. In this study, we investigated 19 inpatients with opioid dependence receiving treatment-as-usual (TAU, n = 9) or additional MBI (n = 10). Structural magnetic resonance imaging data were acquired before and after four weeks of treatment. Source-based morphometry was used to investigate modulation of structural networks after treatment. Both treatment modalities led to significant clinical improvement. Patients receiving MBI showed a significant change in distress tolerance levels. An increase in bilateral striatal/insular and prefrontal/cingulate network strength was found in patients receiving MBI compared to individuals receiving TAU. Prefrontal/cingulate cortical network strength was associated with impulsivity levels. These findings suggest that MBI can have a recognizable role in treatment of substance use disorders and that neural effects of MBI may be captured in terms of frontostriatal structural network change. |
| Databáze: | OpenAIRE |
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