Advances in the development of gene therapy, noncoding RNA, and exosome-based treatments for tendinopathy
| Autor: | Angela Wang Ilaltdinov, Hui B. Sun, Yubao Gong, Daniel J. Leong, Konrad I. Gruson, Deyou Zheng, Li Sun, David T. Fung |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Genetic enhancement Inflammation Bioinformatics Exosomes Exosome General Biochemistry Genetics and Molecular Biology Tendons 03 medical and health sciences 0302 clinical medicine History and Philosophy of Science microRNA medicine Humans Wound Healing business.industry General Neuroscience Genetic Therapy medicine.disease Non-coding RNA Microvesicles Tissue Degeneration MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Tendinopathy medicine.symptom business |
| Zdroj: | Annals of the New York Academy of SciencesReferences. 1490(1) |
| ISSN: | 1749-6632 |
| Popis: | Tendinopathy is a common musculoskeletal disorder characterized by chronic low-grade inflammation and tissue degeneration. Tendons have poor innate healing ability and there is currently no cure for tendinopathy. Studies elucidating mechanisms underlying the pathogenesis of tendinopathy and mechanisms mediating the genesis of tendons during development have provided novel targets and strategies to enhance tendon healing and repair. This review summarizes the current understanding and treatments for tendinopathy. The review also highlights recent advances in gene therapy, the potential of noncoding RNAs, such as microRNAs, and exosomes, which are nanometer-sized extracellular vesicles secreted from cells, for the treatment of tendinopathy. |
| Databáze: | OpenAIRE |
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