Pattern and Risk Factors of Central Compartment Lymph Node Metastasis in Papillary Thyroid Cancer: A Prospective Study from an Endocrine Surgery Centre
| Autor: | Smita Mishra, Gaurav Agarwal, Amit Agarwal, Anjali Mishra, Gyan Chand, Abhai Verma, Sushila Jaiswal, Sudhi Agarwal |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
lcsh:RC648-665 Article Subject business.industry Endocrinology Diabetes and Metabolism medicine.medical_treatment Thyroidectomy medicine.disease lcsh:Diseases of the endocrine glands. Clinical endocrinology Papillary thyroid cancer Surgery Metastasis Endocrine surgery Dissection Clinical Study medicine Histopathology Lymph business Prospective cohort study |
| Zdroj: | Journal of Thyroid Research Journal of Thyroid Research, Vol 2012 (2012) |
| ISSN: | 2042-0072 2090-8067 |
| DOI: | 10.1155/2012/436243 |
| Popis: | Lymphatic metastasis in papillary thyroid cancer (PTC) is eminent; however, the extent of central compartment lymph nodes dissection (CCD) is controversial and requires the knowledge of pattern and risk factors for central compartment lymph nodes metastasis (CCM). We did a prospective study of 47 cases with PTC who underwent total thyroidectomy (TT) with CCD with/without lateral lymph nodes dissection (LND). Clinicopathological profile including CCM as ipsilateral and contralateral was documented. On histopathology, the mean tumour size was3.57±2.42 cm 59.6% had CCM, which was bilateral in the majority (60.72%). The tumour-size was the most important predictor for lymph nodes metastasis-(P=0.018) whereas multicentricity-(P=0.002) and ipsilateral CCM-(P=0.001) were the predictors for contralateral CCM. The long-term morbidity of CCD done in primary setting is comparable with TT-alone. Bilateral CCD should be done with thyroidectomy in PTC, otherwise the risk of residual diseases and subsequent recurrence is high. The long-term morbidity is comparable in experienced hands. |
| Databáze: | OpenAIRE |
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