Hydrophilic and anti-adhesive modification of porous polymer microneedles for rapid dermal interstitial fluid extraction
| Autor: | Lianbin Zhang, Jintao Zhu, Du Hongyao, Liu Pei, Zhuoli Wu, Juan Tao, Hua Wang |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
Polymers Surface Properties Biomedical Engineering Mice chemistry.chemical_compound Polylactic acid PEG ratio Cell Adhesion Animals General Materials Science Polysulfone Particle Size chemistry.chemical_classification Mice Inbred BALB C Molecular Structure technology industry and agriculture Extracellular Fluid General Chemistry General Medicine Adhesion Polymer Polyvinylidene fluoride Glucose chemistry Chemical engineering Needles Point-of-Care Testing NIH 3T3 Cells Female Hydrophobic and Hydrophilic Interactions Porosity Ethylene glycol Phase inversion |
| Zdroj: | Journal of Materials Chemistry B. 9:5476-5483 |
| ISSN: | 2050-7518 2050-750X |
| DOI: | 10.1039/d1tb00873k |
| Popis: | Porous polymer microneedles (MNs) with interconnected structures demonstrate great potential in dermal interstitial fluid (ISF) extraction. However, the fluid extraction rate and the recovery of the extracted ISF by the porous MNs are limited by the poor hydrophilicity and the adhesion of porous MNs. Herein, we present a facile and mild polydopamine (PDA) and poly(ethylene glycol) (PEG) coating strategy for hydrophilic and anti-adhesive modification of porous polymer MNs from a phase inversion method. As a proof-of-concept, taking polysulfone (PSF) as an example, PDA and PEG-coated MNs (PSF@PDA@PEG) are fabricated through the self-polymerization of dopamine and PEG anchoring. Thanks to the hydrophilicity and anti-adhesion of PEG, the resulting PSF@PDA@PEG MNs demonstrate improved hydrophilicity, fast fluid extraction speed, and low target molecular adhesion. Besides, this method can be extended to hydrophobic polymers generally used in medical fields, including polylactic acid (PLA), polyvinylidene fluoride (PVDF), etc. This investigation provides a new road for MN-based off-line analysis in point-of-care testing (POCT). |
| Databáze: | OpenAIRE |
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