Nigral damage and dopaminergic hypofunction in mesencephalon-immunized guinea pigs
Autor: | Lanny J. Haverkamp, Stanley H. Appel, Wei‐Dong ‐D Le, János Tajti, József I. Engelhardt |
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Rok vydání: | 1992 |
Předmět: |
Central Nervous System
Male Pathology medicine.medical_specialty Tyrosine 3-Monooxygenase Dopamine animal diseases Guinea Pigs chemical and pharmacologic phenomena Substantia nigra Striatum Biology Autoimmune Diseases Guinea pig Midbrain Basal ganglia medicine Animals Humans Brain Diseases Dopaminergic biochemical phenomena metabolism and nutrition Immunohistochemistry Pathophysiology Substantia Nigra Spinal Cord nervous system Neurology Immunoglobulin G bacteria Cattle Neurology (clinical) medicine.drug |
Zdroj: | Annals of Neurology. 32:494-501 |
ISSN: | 1531-8249 0364-5134 |
Popis: | To support a potential role for immune mechanisms in the destruction of substantia nigra (SN) neurons, guinea pigs were immunized with bovine mesencephalon containing SN neurons. After immunization no clinical signs of basal ganglia dysfunction appeared. However, pathological examination revealed evidence of neuronal damage in the SN in 8 of 17 guinea pigs immunized with bovine mesencephalon. No nigral pathology was noted in animals immunized with spinal cord gray matter or Freund's adjuvant alone. Accompanying the SN damage in mesencephalon-immunized guinea pigs was a 25% decrease in tyrosine hydroxylase activity in the SN and a 27% decrease in dopamine content in the striatum. Deposits of IgG were detected by immunohistochemical techniques in sections of SN from mesencephalon-immunized guinea pigs and in sections of human SN after exposure to serum from mesencephalon-immunized guinea pigs. These data document the antigenicity of SN and suggest the possibility that immune mechanisms can contribute to basal ganglia pathology. |
Databáze: | OpenAIRE |
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