Renal concentrating capacity test using desmopressin at bedtime
| Autor: | U. Jodal, Jens Peter Nørgaard, Asa Rembratt, Staffan Mårild |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Nephrology
Male medicine.medical_specialty Time Factors Adolescent Renal Agents Bedtime Kidney Concentrating Ability Internal medicine Medicine Humans Deamino Arginine Vasopressin Desmopressin Child Cross-Over Studies business.industry Reproducibility of Results Crossover study Confidence interval Surgery Clinical trial Regimen Anesthesia Child Preschool Pediatrics Perinatology and Child Health Female business medicine.drug Antidiuretic |
| Zdroj: | Pediatric nephrology (Berlin, Germany). 16(5) |
| ISSN: | 0931-041X |
| Popis: | A crossover trial was undertaken to evaluate the bedtime administration of desmopressin (Minirin) as a renal concentrating capacity test (RCCT). Medication was given intranasally as a single 20-microgram dose to 58 children ranging from 3 to 15 years of age with suspected or known renal impairment. The night-time test was shown to be a simple and effective means of assessing renal concentrating capacity. Comparison with the standard daytime test resulted in a 60 mosmol/kg higher mean osmolality in the night-time test. The results were reproducible, with a 95% confidence interval of -26 to 43 mosmol/kg. The procedure was easy to perform, with 51 of 52 patients (or their parents) preferring the night-time regimen compared with the daytime test. Night-time desmopressin therefore offers the potential of a user-friendly RCCT in patients with suspected impairment of renal tubular function. |
| Databáze: | OpenAIRE |
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