Effect of Diabetes Mellitus and Hypertension on Osmotic Fragility and Hemorheological Factors in Male Wistar Rats
| Autor: | Mariam Onono Yusuf, K.K. Anachuna, Jerome Ndudi Asiwe, Damilola Ifeoluwa Alawode, Kamaldeen Olalekan Sanusi, Emuesiri Goodies Moke, Adesoji Adedipe Fasanmade, Ebunoluwa Oluwabusola Adagbada, David Ehikhuemen Okonofua |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Mean arterial pressure endocrine system hypertension endocrine system diseases QH301-705.5 Blood viscosity high salt diet Fibrinogen Diabetes mellitus Internal medicine medicine Biology (General) hemorheology business.industry Erythrocyte fragility nutritional and metabolic diseases General Medicine medicine.disease Streptozotocin Blood proteins Endocrinology diabetes mellitus viscosity Hemorheology business medicine.drug |
| Zdroj: | Biology, Medicine & Natural Product Chemistry, Vol 10, Iss 2, Pp 73-79 (2021) |
| ISSN: | 2540-9328 2089-6514 |
| Popis: | Diabetes mellitus is a common risk factor for erythrocyte osmotic stress. This study was aimed at exploring the effect of streptozotocin (STZ)-induced diabetes mellitus and salt-induced hypertension on osmotic fragility and hemorheological variables in male Wistar rats. Thirty male rats were grouped into five groups of six animals each as follows: negative control (zero salt in diet); positive control (normal salt diet - 0.3% salt); high salt diet (8% salt) (HSD only); STZ induced diabetes and normal salt diet (STZ only); STZ induced diabetes and high salt diet (STZ + HSD). At the end of a 4 weeks period, hematological variables, osmotic fragility, rheology and cardiovascular responses were assessed. There was an increase (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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