Fatal interstitial pneumonitis in a patient with relapsed diffuse large B cell lymphoma following yttrium-90 ibritumomab tiuxetan
| Autor: | Moon Jin Kim, Hyun-Jung Kim, Jong Woo Seo, Cheolwon Suh, Sung-Nam Lim, Gyeong-Won Lee |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Yttrium-90 Ibritumomab Tiuxetan medicine.medical_specialty Biopsy medicine.medical_treatment Ibritumomab tiuxetan Lung biopsy Interstitial pneumonitis Fatal Outcome Recurrence medicine Humans Pharmacology (medical) Lung Pharmacology business.industry Antibodies Monoclonal medicine.disease Oncology Methylprednisolone Radioimmunotherapy Immunology Etiology Female Radiography Thoracic Lymphoma Large B-Cell Diffuse Radiology Lung Diseases Interstitial business Diffuse large B-cell lymphoma medicine.drug |
| Zdroj: | Investigational New Drugs. 29:1098-1101 |
| ISSN: | 1573-0646 0167-6997 |
| DOI: | 10.1007/s10637-010-9460-0 |
| Popis: | There is no previous report of fatal interstitial pneumonitis related to the administration of yttirum-90 ibritumomab tiuxetan. We report first case of fatal interstitial pneumonitis in a 35-year-old female patient with relapsed diffuse large B cell lymphoma following yttrium-90 ibritumomab tiuxetan. A pathological evaluation through a surgical lung biopsy demonstrated a "interstitial pneumonitis" pattern. Although high-dose methylprednisolone was administered, she died due to acute respiratory distress syndrome, secondary to radioimmunotherapy-induced interstitial pneumonitis. In this report, we discuss the etiology, diagnosis, and management of radioimmunotherapy-induced interstitial pneumonitis. |
| Databáze: | OpenAIRE |
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