Smoking and other risk factors for pancreatic cancer: a cohort study in men in Lithuania
| Autor: | Regina Reklaitiene, Ruta Everatt, Egle Milinaviciene, Irena Kuzmickiene, Dalia Virviciute, Abdonas Tamosiunas, Ričardas Radišauskas |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty 616.37-006.6 [udc] Alcohol Drinking Epidemiology Population Body Mass Index Risk Factors Internal medicine Pancreatic cancer medicine Humans Prospective Studies Risk factor Prospective cohort study education Life Style education.field_of_study business.industry Incidence Hazard ratio Smoking Cancer Pancreatic neoplasms Risk factors Adverse effects Alcohol drinking Cholesterol Blood Lithuania Cohort studies Middle Aged medicine.disease Prognosis Surgery Pancreatic Neoplasms Oncology Case-Control Studies business Body mass index Cohort study Follow-Up Studies |
| Zdroj: | Cancer epidemiology, Amsterdam : Elsevier, 2013, vol. 37, no. 2, p. 133-139 |
| ISSN: | 1877-783X 1877-7821 |
| Popis: | Background: Cancer of the pancreas is a relatively rare, but highly fatal cancer worldwide. Cigarette smoking has been recognized as an important risk factor, but the relation to other potential determinants is still inconsistent. We investigated the association between different lifestyle, biological and anthropometric factors and the risk of pancreatic cancer in a prospective population-based cohort study from Kaunas, Lithuania. Methods: Our study included 7132 urban men initially free from any diagnosed cancer, followed for up to 30 years. 77 incident cases of pancreatic cancer were identified. Cox proportional hazards regression models were used to estimate hazard ratios (HR) and corresponding 95% confidence intervals (95% CI). Results: Compared to never smokers, current smokers had a significantly increased risk of pancreatic cancer, HR was 1.79 (95% CI 1.03–3.09) after adjustment for age, body mass index, education and alcohol consumption. Among smokers, a significant association with higher smoking intensity was shown ( 20 cigarettes/day: HR = 2.60; 95% CI 1.42–4.76, Ptrend = 0.046). We also observed a significantly increased risk for 30 pack-years of smoking (HR = 2.24; 95% CI 1.12–4.49, Ptrend = 0.16) and for age at starting smoking |
| Databáze: | OpenAIRE |
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