Insulin resistance and NAFLD may influence memory performance in obese patients with prediabetes or newly-diagnosed type 2 diabetes
| Autor: | Francesco Vadini, Francesca Santilli, Giovambattista Desideri, Sonia Ciotti, Augusto Di Castelnuovo, Maria Teresa Guagnano, Paola Simeone, Rossella Liani, Francesco Cipollone, Romina Tripaldi, Agostino Consoli, Armando Tartaro |
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| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Type 2 diabetes Risk Assessment Gastroenterology Prediabetic State Cognition Insulin resistance Memory Non-alcoholic Fatty Liver Disease Risk Factors Internal medicine Diabetes mellitus Humans Hypoglycemic Agents Medicine Cognitive Dysfunction Obesity Prediabetes Cognitive decline Memory Disorders Nutrition and Dietetics business.industry Fatty liver Age Factors Type 2 Diabetes Mellitus Middle Aged medicine.disease Metformin Diabetes Mellitus Type 2 Female Insulin Resistance Cardiology and Cardiovascular Medicine business |
| Zdroj: | Nutrition, Metabolism and Cardiovascular Diseases. 31:2685-2692 |
| ISSN: | 0939-4753 |
| Popis: | Background and aims Diabetes has consistently been shown to increase risk for cognitive decline. Cognitive deficits may occur at the very earliest stages of diabetes. We sought to estimate the determinants of memory function in a group of middle-aged obese subjects with prediabetes or newly-diagnosed type 2 diabetes mellitus. Methods and results Sixty-two obese patients in treatment with metformin-with prediabetes (n = 41) or newly diagnosed T2DM (n = 21), were studied. Short- and long-term memory function was assessed through a neuropsychological assessment consisting of two tests and a composite domain z score was calculated. Cardiometabolic variables, such as abdominal MRI quantification of subcutaneous (SAT) and visceral (VAT) adipose tissue content, and of intra-hepatocellular lipid content, as well as insulin sensitivity (Matsuda Index, HOMA-IR) and beta cell performance (Beta Index), by multiple sampling, 8-point oral glucose tolerance test, were also evaluated. Age, non-alcoholic fatty liver disease (NAFLD), and lnHOMA-IR together explained 18% (R square) of the variance in memory domain. Including NAFLD increased the explained variance by 8% and including lnHOMA-IR by 9.1%, whereas the contribution of age and other factors was negligible. Conclusion Preventing and managing insulin resistance in precocious and possibly earlier stages of diabetes might provide benefit in slowering down future cognitive decline. |
| Databáze: | OpenAIRE |
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