Radiosensitizer-eluting nanocoatings on gold fiducials for biologicalin-situimage-guided radio therapy (BIS-IGRT)
| Autor: | G Makrigiorgos, Evin Gultepe, C O Levy, Dayane Batista Tada, Robert A. Cormack, E Jost, Dattatri Nagesha, Srinivas Sridhar, C K K Stambaugh |
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| Rok vydání: | 2010 |
| Předmět: |
Radiation-Sensitizing Agents
Radiosensitizer Materials science medicine.medical_treatment Brachytherapy Nanoparticle Nanotechnology Chitosan chemistry.chemical_compound Fiducial Markers medicine Humans Polymethyl Methacrylate Radiology Nuclear Medicine and imaging Methyl methacrylate Image-guided radiation therapy Drug Carriers Radiological and Ultrasound Technology Nanoporous Radiotherapy Planning Computer-Assisted technology industry and agriculture Kinetics PLGA chemistry Doxorubicin Nanoparticles Gold |
| Zdroj: | Physics in Medicine and Biology. 55:6039-6052 |
| ISSN: | 1361-6560 0031-9155 |
| DOI: | 10.1088/0031-9155/55/20/001 |
| Popis: | Image-guided radiation treatments (IGRT) routinely utilize radio-opaque implantable devices, such as fiducials or brachytherapy spacers, for improved spatial accuracy. The therapeutic efficiency of IGRT can be further enhanced by biological in situ dose painting (BIS-IGRT) of radiosensitizers through localized delivery within the tumor using gold fiducial markers that have been coated with nanoporous polymer matrices loaded with nanoparticles (NPs). In this work, two approaches were studied: (i) a free drug release system consisting of Doxorubicin (Dox), a hydrophilic drug, loaded into a non-degradable polymer poly(methyl methacrylate) (PMMA) coating and (ii) poly(d,l-lactic-co-glycolic acid) (PLGA) NPs loaded with fluorescent Coumarin-6, serving as a model for a hydrophobic drug, in a biodegradable chitosan matrix. Temporal release kinetics measurements in buffer were carried out using fluorescence spectroscopy. In the first case of free Dox release, an initial release within the first few hours was followed by a sustained release over the course of the next 3 months. In the second platform, release of NPs and the free drug was controlled by the degradation rate of the chitosan matrix and PLGA. The results show that dosage and rate of release of these radiosensitizers coated on gold fiducials for IGRT can be precisely tailored to achieve the desired release profile for radiation therapy of cancer. |
| Databáze: | OpenAIRE |
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