Association of hepatitis C virus infection and liver fibrosis severity with the variants alleles of MBL2 gene in a Brazilian population
| Autor: | Patrícia Moura, Erika Rabelo Forte de Siqueira, Luydson Richardson Silva Vasconcelos, Leila Maria Moreira Beltrão Pereira, Luciano Pereira, Maria Cristina Halla, Maria do Socorro de Mendonça Cavalcanti, Rodrigo Feliciano do Carmo |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Liver Cirrhosis Male Heterozygote Genotype Hepatitis C virus Immunology Single-nucleotide polymorphism Hepacivirus Biology medicine.disease_cause Mannose-Binding Lectin Polymorphism Single Nucleotide Severity of Illness Index Young Adult Gene Frequency Fibrosis medicine Humans Immunology and Allergy Promoter Regions Genetic Aged Mannan-binding lectin Hepatitis medicine.diagnostic_test Homozygote Haplotype Exons General Medicine Hepatitis C Middle Aged medicine.disease Haplotypes Liver biopsy Female Brazil |
| Zdroj: | Human Immunology. 71:883-887 |
| ISSN: | 0198-8859 |
| DOI: | 10.1016/j.humimm.2010.05.021 |
| Popis: | Mannose binding lectin (MBL) is a molecule of the innate immunity, which activates the complement system and modulates inflammation. We investigated the association of the polymorphisms in the exon 1 and promoter region of the MBL gene (MBL2) with the susceptibility to hepatitis C virus (HCV) infection and the degree of liver fibrosis in Brazilian patients chronically infected with HCV. The study was performed in 232 healthy control subjects and 186 patients, 157 of whom underwent liver biopsy after histopathology analysis and classification of fibrosis according to Metavir score. Exon 1 was genotyped by melting temperature assay and the promoter region by Taqman real-time polymerase chain reacation. The frequency of genotypes related to low production of MBL was higher in patients with HCV than in controls (p(c) = 0.0001, odds ratio = 3.52; confidence interval = 1.86-6.71). In addition, the frequency of variant haplotype, HYO was higher in patients with the severe fibrosis stage F4 (10.7%) than in patients with the mild/moderate fibrosis stage F1/F2 (3.4%), when compared with the HYA haplotype (p(c) = 0.04, odds ratio = 5.25, confidence interval = 1.11-23.62). We conclude that MBL variant alleles expressing low levels of MBL are associated with the susceptibility to HCV infection and that the inheritance of HYO haplotype could be associated with fibrosis severity. |
| Databáze: | OpenAIRE |
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