The Brain Donation Program in South Korea
| Autor: | Jae Bum Kim, Sung Mi Shim, Eun-Joo Kim, Jung Seok Lee, Kyung-Hoon Lee, Ho-Won Lee, Tae Sung Lim, Seung Joo Kim, Moon Hwan Bae, Duk L. Na, Hyun Wook Kang, Young Ho Koh, Hee Jin Kim, William W. Seeley, Kyung Chan Choi, Hyun Joung Lim, Kyung-Hwa Lee, Yuna Kim, Gi Yeong Huh, Min-Cheol Lee, Yeshin Kim, Sang Won Seo, Yeon-Lim Suh, Byeong C. Kim |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Pediatrics medicine.medical_specialty Biopsy Neurological examination Disease Neuropathology Neuropsychological Tests frontotemporal dementia Creutzfeldt-Jakob Syndrome Primary progressive aphasia Leukoencephalopathy 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Republic of Korea mental disorders Humans Medicine Dementia Aged medicine.diagnostic_test Neurology & Neurosciences business.industry brain autopsy Patient Selection Neuropsychology amyloid Brain Neurodegenerative Diseases General Medicine Alzheimer's disease Middle Aged medicine.disease Magnetic Resonance Imaging 030104 developmental biology Positron-Emission Tomography Original Article Female business 030217 neurology & neurosurgery Frontotemporal dementia |
| Zdroj: | Yonsei Medical Journal |
| ISSN: | 1976-2437 0513-5796 |
| Popis: | Purpose Obtaining brain tissue is critical to definite diagnosis and to furthering understanding of neurodegenerative diseases. The present authors have maintained the National Neuropathology Reference and Diagnostic Laboratories for Dementia in South Korea since 2016. We have built a nationwide brain bank network and are collecting brain tissues from patients with neurodegenerative diseases. We are aiming to facilitate analyses of clinic-pathological and image-pathological correlations of neurodegenerative disease and to broaden understanding thereof. Materials and methods We recruited participants through two routes: from memory clinics and the community. As a baseline evaluation, clinical interviews, a neurological examination, laboratory tests, neuropsychological tests, and MRI were undertaken. Some patients also underwent amyloid PET. Results We recruited 105 participants, 70 from clinics and 35 from the community. Among them, 11 died and were autopsied. The clinical diagnoses of the autopsied patients included four with Alzheimer's disease (AD), two with subcortical vascular dementia, two with non-fluent variant primary progressive aphasia, one with leukoencephalopathy, one with frontotemporal dementia (FTD), and one with Creutzfeldt-Jakob disease (CJD). Five patients underwent amyloid PET: two with AD, one with mixed dementia, one with FTD, and one with CJD. Conclusion The clinical and neuropathological information to be obtained from this cohort in the future will provide a deeper understanding of the neuropathological mechanisms of cognitive impairment in Asia, especially Korea. |
| Databáze: | OpenAIRE |
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