The importance of circulating and disseminated tumor cells in pancreatic cancer
| Autor: | Barbara Aldana Blanco, Alina Hasanain, Jun Yu, Christopher L. Wolfgang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Resectable Pancreatic Cancer medicine.medical_specialty Early Recurrence business.industry Mesenchymal stem cell lcsh:Surgery Tumor cells lcsh:RD1-811 Disease medicine.disease Phenotype Article Circulating tumor cell Mediator Internal medicine Pancreatic cancer Cancer research Medicine In patient business |
| Zdroj: | Surgery Open Science Surgery Open Science, Vol 1, Iss 2, Pp 49-55 (2019) |
| ISSN: | 2589-8450 |
| Popis: | Pancreatic cancer is a lethal disease in a large part due to the systemic nature at the time of diagnosis. In those patients who undergo a potentially curative resection of pancreatic cancer, the overwhelming majority will have systemic relapse. Circulating tumor cells are an important mediator of the development of metastases. Circulating tumor cells have been identified in patients with clinically localized resectable pancreatic cancer and exist as several phenotypes. Mesenchymal and stem cell–like phenotypes of circulating tumor cells predict early recurrence and worse survival. This review focuses on the current understanding of circulating tumor cells in pancreatic cancer and how this information can be used in developing more effective therapy in the future. |
| Databáze: | OpenAIRE |
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