S100A8/A9 complex as a new biomarker in prediction of mortality in elderly patients with severe heart failure
| Autor: | Masatoshi Fujita, Li-Ping Ma, Masaki Ikemoto, Fumio Terasaki, Michael Fu, Espen Haugen |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Population S100A8/A9 Complex Severity of Illness Index Predictive Value of Tests Internal medicine Severity of illness medicine Calgranulin B Humans Calgranulin A Intensive care medicine education Survival rate Aged Aged 80 and over Heart Failure education.field_of_study business.industry Proportional hazards model Interleukin-6 Age Factors medicine.disease Survival Rate Predictive value of tests Heart failure Cardiology Biomarker (medicine) Female Cardiology and Cardiovascular Medicine business Biomarkers Follow-Up Studies |
| Zdroj: | International journal of cardiology. 155(1) |
| ISSN: | 1874-1754 |
| Popis: | Background S100A8/A9 complex is a new inflammation-related protein and has a positive correlation with C-reaction protein level. However its role in chronic heart failure (CHF) remains unclear. Methods and results Circulating levels of S100A8/A9 complex and other biomarkers (IL-6, IL-8, TNF-α, and BNP) were measured in CHF (n=54) and hypertensive without CHF (n=31) as well as healthy subjects (n=23), with follow up to 1480days. During follow-up, cumulative mortality rate for CHF patients was 63%. Plasma levels of S100A8/A9 complex, IL-6, IL-8 and TNF-α were significantly higher in CHF than the hypertensive patients and healthy subjects. A significant positive correlation was found between S100A8/A9 complex and IL-6 and IL-8 respectively. Cox regression analysis showed that IL-6 and IL-8 were predictors for mortality for 6months, and S100A8/A9 complex, IL-6, IL-8 and age were predictors for mortality for one year whereas BNP, TNF-α, IL-6 and IL-8 remained predictors for mortality for two years. A combination of S100A8/A9 complex and IL-6 provided powerful predictive value in mortality for both 6 and 12months. Conclusions S100A8/A9 complex is a useful biomarker as a predictor for one year mortality and its combination with IL-6 is able to provide additive prognostic information in this vulnerable heart failure population in the elderly. |
| Databáze: | OpenAIRE |
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