Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases
| Autor: | Fulvia Terracciano, Carmela Loguercio, Concetta Tuccillo, Alessandro Federico, Camillo Del Vecchio Blanco, Claudio De Simone, M.V. D'Auria |
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| Přispěvatelé: | Loguercio, Carmelina, Federico, Alessandro, Tuccillo, C., Terracciano, F., Dauria, M. V., DE SIMONE, C., DEL VECCHIO BLANCO, C. |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Cirrhosis Chronic liver disease medicine.disease_cause Gastroenterology Statistics Nonparametric liver disease gut-liver axis bacteria strain Liver disease Liver Function Tests Internal medicine Malondialdehyde Nonalcoholic fatty liver disease medicine Humans Liver Diseases Alcoholic Hepatitis Aldehydes Analysis of Variance S-Nitrosothiols medicine.diagnostic_test business.industry Probiotics Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease Fatty Liver Oxidative Stress Immunology Chronic Disease Cytokines Female Liver function tests business Oxidative stress |
| Popis: | Objectives To evaluate whether chronic therapy with probiotics affects plasma levels of cytokines and oxidative/nitrosative stress parameters, as well as liver damage, in patients with various types of chronic liver disease. Patients and methods A total of 22 nonalcoholic fatty liver disease (NAFLD) and 20 alcoholic liver cirrhosis (AC) patients were enrolled in the study and compared with 36 HCV-positive patients with chronic hepatitis without (20, CH) or with (16, CC) liver cirrhosis. All patients were treated with the probiotic VSL#3. Routine liver tests, plasma levels of tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6 and -10, malondialdehyde (MDA), and 4-hydroxynonenal (4-HNE), S-nitrosothiols (S-NO), were evaluated on days -30, 0, 90, and 120. Results Treatment with VSL#3 exerted different effects in the various groups of patients: in NAFLD and AC groups, it significantly improved plasma levels of MDA and 4-HNE, whereas cytokines (TNF-alpha, IL-6, and IL-10) improved only in AC patients. No such effects were observed in HCV patients. Routine liver damage tests and plasma S-NO levels were improved at the end of treatment in all groups. Conclusions Results of the study suggest that manipulation of intestinal flora should be taken into consideration as possible adjunctive therapy in some types of chronic liver disease. |
| Databáze: | OpenAIRE |
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