Pancreatitis-Associated Protein Does Not Predict Disease Relapse in Inflammatory Bowel Disease Patients

Autor: Jean Charles Dagorn, Teddy Grandjean, Mathias Chamaillard, Juan L. Iovanna, Maria Pellise, Maria José Sandi, Elena Ricart, Miquel Sans, Maria Josefina Etchevers, Julián Panés, Tiago Nunes, Susana Pinó Donnay
Rok vydání: 2014
Předmět:
Male
Pancreatitis-Associated Proteins
Severity of Illness Index
Gastroenterology
Inflammatory bowel disease
Feces
Crohn Disease
Recurrence
Pathology
Prospective Studies
Prospective cohort study
Leukocyte L1 Antigen Complex
Multidisciplinary
biology
Middle Aged
Prognosis
Clinical Laboratory Sciences
C-Reactive Protein
Observational Studies
Small Intestine
Medicine
Female
medicine.symptom
Research Article
Adult
medicine.medical_specialty
Clinical Research Design
Colon
Science
Inflammation
Gastroenterology and Hepatology
Antigens
Neoplasm
Diagnostic Medicine
Internal medicine
Severity of illness
Biomarkers
Tumor
medicine
Humans
Ulcerative Colitis
Lectins
C-Type
Colitis
business.industry
Inflammatory Bowel Disease
C-reactive protein
medicine.disease
digestive system diseases
Immunology
biology.protein
Pancreatitis
Colitis
Ulcerative
business
Biomarkers
General Pathology
Zdroj: PLoS ONE, Vol 9, Iss 1, p e84957 (2014)
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0084957
Popis: BackgroundThe pancreatitis-associated protein (PAP) is increased in the serum of active inflammatory bowel disease (IBD) patients and its levels seem to be correlated with disease activity. Our aim was to evaluate the usefulness of serum and fecal PAP measurements to predict relapse in patients with inactive IBD.Materials and methodsWe undertook a 12-month prospective study that included 66 Crohn's disease (CD) and 74 ulcerative colitis (UC) patients. At inclusion, patients were in clinical remission, defined by a Harvey-Bradshaw (HB) Index≤4 (CD) or a partial Mayo Score (MS)ResultsActive CD patients had an increased mean serum PAP at the diagnosis of the flare (104.1 ng/ml) and 3 months prior to activity (22.68 ng/ml) compared with patients in remission (13.26 ng/ml), pConclusionSerum PAP is increased only in active CD patients, but this marker does not predict disease activity. Inactive UC patients have marked low levels of PAP in fecal samples compared with CD patients.
Databáze: OpenAIRE
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