Prognostic value of posttreatment 18F-FDG PET/CT and predictors of metabolic response to therapy in patients with locally advanced cervical cancer treated with concomitant chemoradiation therapy: an analysis of intensity- and volume-based PET parameters

Autor:	Stefano Fanti, Cristina Nanni, Giulia Dondi, Anna Myriam Perrone, Giulio Vara, Pierandrea De Iaco, Antonella Matti, Giacomo Maria Lima, Eugenia De Crescenzo, Nicoletta Naselli, Alessio G. Morganti
Přispěvatelé:	Lima GM, Matti A, Vara G, Dondi G, Naselli N, De Crescenzo EM, Morganti AG, Perrone AM, De Iaco P, Nanni C, Fanti S.
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Oncology Adult medicine.medical_specialty Uterine Cervical Neoplasms Kaplan-Meier Estimate Logistic regression 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Internal medicine Positron Emission Tomography Computed Tomography medicine Humans Radiology Nuclear Medicine and imaging Stage (cooking) Aged Cervical cancer Aged 80 and over business.industry Retrospective cohort study General Medicine Chemoradiotherapy LACC Middle Aged medicine.disease Chemoradiation therapy Prognosis FDG PET/CT Intensity (physics) Treatment Outcome 030220 oncology & carcinogenesis Concomitant Cohort Original Article Female business Prognostic value
Zdroj:	European Journal of Nuclear Medicine and Molecular Imaging
ISSN:	1619-7089 1619-7070
Popis:	PURPOSE: To investigate the prognostic value of posttreatment 18F-FDG PET/CT in patients with locally advanced cervical cancer (LACC) treated with concomitant chemoradiation therapy (CCRT). The secondary aim was to assess the possible role of intensity-based and volume-based PET parameters including SUVmax, SUVmean, MTV and TLG, and clinical parameters including age, pathology, FIGO stage and nodal involvement as factors predicting response to treatment. METHODS: This retrospective study included 82 patients affected by LACC treated with CCRT. All patients underwent 18F-FDG PET/CT both before and after treatment. The posttreatment PET/CT scans were used to classify patients as complete metabolic responders (CMR) or non-complete metabolic responders (N-CMR) according to the EORTC criteria. Kaplan-Meier analysis was used to evaluate differences in overall survival (OS) between the CMR and N-CMR groups. Student's t test, Pearson's chi-squared test and logistic regression were used to investigate the possible value of PET and clinical parameters as predictors of metabolic response to therapy. RESULTS: Kaplan-Meier analysis showed a highly significant difference in OS between the CMR and N-CMR groups (log-rank test p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef71cd38f7efd139c600f6f6599a4da http://europepmc.org/articles/PMC6182406 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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