Clinical dynamic visual acuity in patients with cerebellar ataxia and vestibulopathy

Autor: Silvia Kmetonyova, Alena Zumrová, Dylan J. Jester, Michaela Dankova, Martin Vyhnalek, Jaroslava Paulasová Schwabová, Rudolf Cerny, Jaroslav Jerabek
Rok vydání: 2021
Předmět:
Visual acuity
Eye Movements
genetic structures
Vision
Physiology
Visual System
medicine.medical_treatment
Sensory Physiology
Visual Acuity
Social Sciences
Audiology
Infographics
Medical Conditions
0302 clinical medicine
Reflexes
Medicine and Health Sciences
Psychology
030223 otorhinolaryngology
Data Management
Visual Impairments
Vestibular system
Movement Disorders
Multidisciplinary
Rehabilitation
Neurodegenerative Diseases
Reflex
Vestibulo-Ocular
Charts
Sensory Systems
Neurology
Vestibular Diseases
Medicine
Sensory Perception
medicine.symptom
Research Article
Computer and Information Sciences
medicine.medical_specialty
Ataxia
Cerebellar Ataxia
Science
03 medical and health sciences
medicine
Humans
Head Impulse Test
Cerebellar ataxia
business.industry
Data Visualization
Cognitive Psychology
Biology and Life Sciences
Head impulse test
medicine.disease
Bilateral vestibulopathy
Ophthalmology
Reflex
Cognitive Science
Perception
sense organs
business
030217 neurology & neurosurgery
Neuroscience
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0255299 (2021)
ISSN: 1932-6203
Popis: Deterioration of dynamic visual acuity (DVA) as a result of impaired vestibulo-ocular reflex (VOR) has been well described in peripheral vestibulopathies, however, changes in DVA in patients with degenerative cerebellar ataxias (CA) and its relation to VOR impairment in these patients has not yet been evaluated. Our aim was to assess the alterations of DVA in CA and to evaluate its relation to vestibular function. 32 patients with CA and 3 control groups: 13 patients with unilateral and 13 with bilateral vestibulopathy and 21 age matched healthy volunteers were examined by clinical DVA test, VOR was assessed by video Head Impulse Test and caloric irrigation. The severity of ataxia in CA was assessed by Scale for the assessment and rating of ataxia (SARA). Relationship between DVA and vestibular function in CA patients was examined by linear regressions. DVA impairment was highly prevalent in CA patients (84%) and its severity did not differ between CA and bilateral vestibulopathy patients. The severity of DVA impairment in CA was linked mainly to VOR impairment and only marginally to the degree of ataxia. However, DVA impairment was present also in CA patients without significant vestibular lesion showing that central mechanisms such as impairment of central adaptation of VOR are involved. We suggest that the evaluation of DVA should be a standard part of clinical evaluation in patients with progressive CA, as this information can help to target vestibular and oculomotor rehabilitation.
Databáze: OpenAIRE
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