Pattern of microbial translocation in patients living with HIV-1 from Vietnam, Ethiopia and Sweden
| Autor: | Mattias Larsson, Lars Lindquist, Babilonia Barqasho, Wondwossen Amogne, Samir Abdurahman, Piotr Nowak, Anders Sönnerborg, Gaetano Marrone, Do Duy Cuong |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Lipopolysaccharides Male microbial translocation LPS AIDS-Related Opportunistic Infections Human immunodeficiency virus (HIV) Lipopolysaccharide Receptors Enzyme-Linked Immunosorbent Assay HIV Infections medicine.disease_cause Immunoglobulin G immune activation medicine Humans In patient Sweden biology business.industry Public Health Environmental and Occupational Health virus diseases HIV in Sweden Middle Aged Viral Load sCD14 Virology HIV in Ethiopia Infectious Diseases Vietnam treatment-naïve patients living with HIV Bacterial Translocation Immunology biology.protein Hiv patients HIV-1 Female Ethiopia HIV in Vietnam business Viral load Flagellin Microbial translocation Research Article |
| Zdroj: | Journal of the International AIDS Society |
| ISSN: | 1758-2652 |
| Popis: | Introduction The role of microbial translocation (MT) in HIV patients living with HIV from low- and middle-income countries (LMICs) is not fully known. The aim of this study is to investigate and compare the patterns of MT in patients from Vietnam, Ethiopia and Sweden. Methods Cross-sectional samples were obtained from treatment-naïve patients living with HIV-1 and healthy controls from Vietnam (n=83; n=46), Ethiopia (n=9492; n=50) and Sweden (n=51; n=19). Longitudinal samples were obtained from a subset of the Vietnamese (n=24) in whom antiretroviral therapy (ART) and tuberculostatics were given. Plasma lipopolysaccharide (LPS), sCD14 and anti-flagellin IgG were determined by the endpoint chromogenic Limulus Amebocyte Assay and enzyme-linked immunosorbent assay. Results All three biomarkers were significantly increased in patients living with HIV-1 from all countries as compared to controls. No differences were found between males and females. Vietnamese and Ethiopian patients had significantly higher levels of anti-flagellin IgG and LPS, as compared to Swedes. ART reduced these levels for the Vietnamese. Vietnamese patients given tuberculostatics at initiation of ART had significantly lower levels of anti-flagellin IgG and higher sCD14. The biomarkers were lower in Vietnamese who did not develop opportunistic infection. Conclusions Higher MT is common in patients living with HIV compared to healthy individuals, and in patients from LMICs compared to patients from a high-income country. Treatment with tuberculostatics decreased MT while higher levels of MT are associated with a poorer clinical outcome. |
| Databáze: | OpenAIRE |
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