Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury

Autor: Esben Budtz-Jørgensen, Pal Weihe, Anna L. Choi, Flemming Nielsen, Philippe Grandjean, Maria Skaalum Petersen, Clara Amalie Gade Timmermann
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Faroe islands
Health (social science)
Epidemiology
Denmark
pilot whale
Physiology
010501 environmental sciences
01 natural sciences
Umbilical cord
Pilot whale
chemistry.chemical_compound
0302 clinical medicine
Pregnancy
Contaminants
Blubber
Medicine
Prospective Studies
030212 general & internal medicine
Prospective cohort study
Methylmercury
PCB
biology
Arctic Regions
methylmercury
General Medicine
Methylmercury Compounds
Fetal Blood
Polychlorinated Biphenyls
Whales
Pilot
medicine.anatomical_structure
Maternal Exposure
DDE
Female
Sex ratio
Research Article
Adult
lcsh:Arctic medicine. Tropical medicine
lcsh:RC955-962
Dichlorodiphenyl Dichloroethylene
Food Contamination
Young Adult
03 medical and health sciences
Journal Article
Animals
Humans
14. Life underwater
0105 earth and related environmental sciences
business.industry
Public Health
Environmental and Occupational Health
Polychlorinated biphenyl
sex ratio
biology.organism_classification
medicine.disease
chemistry
business
Zdroj: Timmermann, C A G, Choi, A L, Petersen, M S, Nielsen, F, Budtz-Jørgensen, E, Weihe, P & Grandjean, P 2017, ' Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury ', International Journal of Circumpolar Health, vol. 76, no. 1, 1406234 . https://doi.org/10.1080/22423982.2017.1406234
Timmermann, C A G, Choi, A L, Petersen, M S, Nielsen, F, Budtz-Jørgensen, E, Weihe, P & Grandjean, P 2017, ' Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury ', International Journal of Circumpolar Health, vol. 76, no. 1, 1406234, pp. 1-8 . https://doi.org/10.1080/22423982.2017.1406234
International Journal of Circumpolar Health, Vol 76, Iss 1 (2017)
International Journal of Circumpolar Health
DOI: 10.1080/22423982.2017.1406234
Popis: This study was undertaken to assess the potential impact of maternal exposures to polychlorinated biphenyl (PCB), dichlorodiphenyl dichloroethylene (DDE) and methylmercury on the secondary sex ratios (the ratio of male to female live births) over a span of 23 years. The study includes prospective data from three Faroese birth cohorts, with a total of 2,152 healthy mother–child dyads recruited between 1986 and 2009. The Faroe Islands is a subarctic fishing community, where pilot whale meat and blubber are part of the traditional marine diet. Exposures were measured in maternal hair, serum or umbilical cord blood. Confounder adjusted logistic regression models were used to assess the associations between maternal exposures and the secondary sex ratio. A doubling in ΣPCB, p,p’-DDE and mercury concentrations were associated with increased odds by 8% (95% CI = 0–16%), 7% (95% CI = 0–14%) and 9% (95% CI = 2–17%), respectively, of giving birth to a boy. In conclusion, maternal exposure to ΣPCB, DDE and methylmercury was associated with a slightly increased secondary sex ratio. The impact of paternal exposures could not be taken into account and deserves attention.
Databáze: OpenAIRE
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