Neonatal basolateral amygdala lesions affect monoamine and cannabinoid brain systems in adult rats
| Autor: | Hans Bouwmeester, Mirjam A. F. M. Gerrits, Jolanda Snapper, Jan M. van Ree, H.G.M. Westenberg, John G. Roozemond, Chris G. Kruse, Eric Ronken |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Serotonin Dopamine medicine.medical_treatment Neonatal Lesion Amygdala Lesion Norepinephrine Receptor Cannabinoid CB1 Cannabinoid Receptor Modulators Excitatory Amino Acid Agonists Image Processing Computer-Assisted medicine Animals Biogenic Monoamines Pharmacology (medical) Rats Wistar Ibotenic Acid Brain Chemistry Pharmacology Behavior Animal Receptors Dopamine D2 Receptors Dopamine D1 Receptors Dopamine D3 Hydroxyindoleacetic Acid Rats Psychiatry and Mental health medicine.anatomical_structure Monoamine neurotransmitter Animals Newborn Dopamine receptor Autoradiography Cannabinoid medicine.symptom Psychology Neuroscience Basolateral amygdala medicine.drug |
| Zdroj: | The International Journal of Neuropsychopharmacology. 10 |
| ISSN: | 1469-5111 1461-1457 |
| DOI: | 10.1017/s1461145706007346 |
| Popis: | There is evidence for neurodevelopment disturbances in schizophrenia. In rats, a neonatal basolateral amygdala lesion induces behavioural features in adults reminiscent of the symptomatology of schizophrenia. Dopamine plays a key role in the pathogenesis of schizophrenia, and cannabis use has been implicated in the risk for developing schizophrenia. The effects of an excitotoxic, bilateral basolateral amygdala lesion on postnatal days 7 or 21 were compared when the rats were adult. The behavioural response to a novelty challenge and the level of dopamine receptors and cannabinoid receptors in the brain using in-vitro autoradiography was determined. In brain tissue punches concentrations of monoamines and metabolites were determined by high-performance liquid chromatography. The neonatal lesion, but not the later lesion induced behavioural hyperactivity and biochemical effects. The neonatal lesion reduced the density of dopamine D 2 -like, but not D 3 -, and less markely D 1 -like receptors and increased dopamine turnover. These effects were observed in the mesolimbic, but not in the striatal regions. In contrast, density of cannabinoid receptors was increased in the striatal, but not the mesolimbic regions of these animals. Noradrenergic neurotransmission was reduced in both regions. The present findings contribute to the idea that the neonatal basolateral amygdala lesion induces features in adults reminiscent of the neurodevelopmental disturbances in schizophrenia, with a focus on the amygdalaprefrontal cortex-nucleus accumbens circuit. |
| Databáze: | OpenAIRE |
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