Is brain response to food rewards related to overeating? A test of the reward surfeit model of overeating in children
| Autor: | Kathleen L. Keller, Shana Adise, Charles F. Geier, Corey N. White, Nicole J. Roberts |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Pediatric Obesity Prefrontal Cortex Hyperphagia Models Psychological Overweight Weight Gain Article Childhood obesity Developmental psychology Eating 03 medical and health sciences 0302 clinical medicine Reward medicine Humans Overeating Child Prefrontal cortex Meals General Psychology Meal 030109 nutrition & dietetics Nutrition and Dietetics medicine.diagnostic_test digestive oral and skin physiology Brain medicine.disease Magnetic Resonance Imaging Dorsolateral prefrontal cortex medicine.anatomical_structure Regression Analysis Female medicine.symptom Functional magnetic resonance imaging Psychology Weight gain psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Appetite |
| ISSN: | 0195-6663 |
| Popis: | The reward surfeit model of overeating suggests that heightened brain response to rewards contributes to overeating and subsequent weight gain. However, previous studies have not tested whether brain response to reward is associated with food intake, particularly during childhood, a period of dynamic development in reward and inhibitory control neurocircuitry. We conducted functional magnetic resonance imaging (fMRI) with 7–11-year-old children (n = 59; healthy weight, n = 31; overweight, n = 28; 54% female) while they played a modified card-guessing paradigm to examine blood-oxygen-level-dependent (BOLD) response to anticipating and winning rewards (food, money, neutral). Food intake was assessed at three separate meals that measured different facets of eating behavior: 1) typical consumption (baseline), 2) overindulgence (palatable buffet), and 3) eating in the absence of hunger (EAH). A priori regions of interest included regions implicated in both reward processing and inhibitory control. Multiple stepwise regressions were conducted to examine the relationship between intake and BOLD response to rewards. Corrected results showed that a greater BOLD response in the medial prefrontal cortex for anticipating food compared to money positively correlated with how much children ate at the baseline and palatable buffet meals. BOLD response in the dorsolateral prefrontal cortex for winning food compared to money was positively correlated with intake at the palatable buffet meal and EAH. All aforementioned relationships were independent of child weight status. Findings support the reward surfeit model by showing that increased brain response to food compared to money rewards positively correlates with laboratory measures of food intake in children. |
| Databáze: | OpenAIRE |
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