TGF-β1 polymorphism in American tegumentary leishmaniasis in a Southern Brazilian population
| Autor: | Sandra Mara Alessi Aristides, Rosiane Ribeiro dos Santos, Waldir Veríssimo da Silva Junior, Rejane Cristina Ribas-Silva, Laiane Alzira Denski da Silva, Sueli Donizete Borelli, Thaís Gomes Verzignassi Silveira, Adriana Danmvolf Ribas, Fabiane Vieira Berg Shehadeh |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male law.invention 0302 clinical medicine law Polymorphism (computer science) Genotype Polymerase chain reaction education.field_of_study Gene polymorphisms Middle Aged Interleukin-10 Infectious Diseases Cytokines Female Brazil Microbiology (medical) Adult Genotyping lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 030106 microbiology 030231 tropical medicine Population Leishmaniasis Cutaneous Biology Transforming Growth Factor beta1 03 medical and health sciences Interferon-gamma Cutaneous leishmaniasis medicine Humans Genetic Predisposition to Disease Allele education Alleles Aged Retrospective Studies Polymorphism Genetic Interleukin-6 Tumor Necrosis Factor-alpha Leishmaniasis medicine.disease Molecular biology Case-Control Studies Parasitology Biomarkers |
| Zdroj: | Revista da Sociedade Brasileira de Medicina Tropical, Vol 52, Iss 0 (2019) Revista da Sociedade Brasileira de Medicina Tropical, Volume: 52, Article number: e20170415, Published: 21 FEB 2019 |
| ISSN: | 1678-9849 |
| Popis: | INTRODUCTION: Genetic polymorphisms define the cytokine production leading to susceptibility or resistance to diseases. We studied the cytokine polymorphism in the development of tegumentary leishmaniasis (TL). METHODS: Genotyping of TNF-α, TGF-β1, IFN-γ, IL-6, and IL-10 were performed by polymerase chain reaction assay. RESULTS: G and C alleles of TGF- β1 (codon 25) were the most common in controls and patients, respectively. G/G was the most frequent genotype in controls, and G/C and C/C in patients. CONCLUSIONS: G/G genotype of codon 25 in TGF-β1 appeared to confer resistance, and G/C and C/C genotypes, susceptibility to TL in this population. |
| Databáze: | OpenAIRE |
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