Development and Biological Evaluation of Inkjet Printed Drug Coatings on Intravascular Stent
| Autor: | Min Zhao, Jonathan Moffat, Bernard Martel, Blandine Maurel, Feng Chai, Jonathan Sobocinski, Nicolaos Scoutaris, Dennis Douroumis, Duncan Q.M. Craig, Nicolas Blanchemain |
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| Rok vydání: | 2015 |
| Předmět: |
Drug
Materials science Paclitaxel Scanning electron microscope Polymers media_common.quotation_subject medicine.medical_treatment Pharmaceutical Science Nanotechnology 02 engineering and technology engineering.material 010402 general chemistry Microscopy Atomic Force 01 natural sciences Drug Delivery Systems Restenosis Coating Coated Materials Biocompatible Drug Discovery Microscopy medicine QD Inkjet printing media_common chemistry.chemical_classification technology industry and agriculture Stent Drug-Eluting Stents Polymer equipment and supplies 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences chemistry engineering Microscopy Electron Scanning Molecular Medicine Cytokines 0210 nano-technology Biomedical engineering |
| Zdroj: | Molecular pharmaceutics. 13(1) |
| ISSN: | 1543-8392 1543-8384 |
| Popis: | Inkjet–printing technology was used to apply biodegradable and biocompatible polymeric coatings of poly(D, L lactide) with the antiproliferative drugs simvastatin (SMV) and paclitaxel (PCX) on coronary metal stents. A piezoelectric dispenser applied coating patterns of very fine droplets (300 xL) and ink jetting was optimized to develop uniform, accurate and reproducible coatings of high yields on the stent strut. The drug loaded polymeric coatings were assed by scanning electron microscopy (SEM), atomic force microscopy (AFM) and transition thermal microscopy (TTM) where a phase separation was observed for SMV/PLA layers while PCX showed a uniform distribution within the polymer layers. Cytocompatibility studies of PLA coatings showed excellent cell adhesion with no decrease of cell viability and proliferation. In vivo stent implantation studies showed significant intra stent restenosis (ISR) for PXC/PLA and PLA plain coatings similar to marketed Presillion (bare metal) and Cypher (drug eluting) stents. The investigation of several cytokine levels after seven days of stent deployment showed no inflammatory response and hence no in vivo cytotoxicity related to PLA coatings. Inkjet printing can be employed as a robust coating technology for the development of drug eluting stents compared to the current conventional approaches. |
| Databáze: | OpenAIRE |
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