TRL, IDL, and LDL Apolipoprotein B-100 and HDL Apolipoprotein A-I Kinetics as a Function of Age and Menopausal Status
| Autor: | Hugh Barrett, Stefania Lamon-Fava, Susan M Jalbert, Ernst J. Schaefer, Alice H. Lichtenstein, Francine K. Welty, Nirupa R Matthan, Gregory G. Dolnikowski |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Aging medicine.medical_specialty Apolipoprotein B Lipoproteins Kinetics chemistry.chemical_compound Leucine Internal medicine medicine Humans Triglycerides Aged Apolipoproteins B Apolipoprotein A-I biology Triglyceride Cholesterol Catabolism Age Factors Cholesterol LDL Middle Aged Deuterium medicine.disease Postmenopause Menopause Endocrinology chemistry Apolipoprotein B-100 biology.protein Female lipids (amino acids peptides and proteins) Lipoproteins HDL Cardiology and Cardiovascular Medicine Lipoprotein |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 25:1691-1696 |
| ISSN: | 1524-4636 1079-5642 |
| DOI: | 10.1161/01.atv.0000172629.12846.b8 |
| Popis: | Objective— To determine mechanisms contributing to the altered lipoprotein profile associated with aging and menopause, apolipoprotein B-100 (apoB-100) and apoA-I kinetic behavior was assessed. Methods and Results— Eight premenopausal (25±3 years) and 16 postmenopausal (65±6 years) women consumed for 6 weeks a standardized Western diet, at the end of which a primed-constant infusion of deuterated leucine was administered in the fed state to determine the kinetic behavior of triglyceride-rich lipoprotein (TRL), intermediate-density lipoprotein (IDL), and low-density lipoprotein (LDL) apoB-100, and high-density lipoprotein (HDL) apoA-I. Data were fit to a multicompartmental model using SAAM II to calculate fractional catabolic rate (FCR) and production rate (PR). Total cholesterol, LDL cholesterol (LDL-C), TRL-C, and triglyceride levels were higher (50%, 55%, 130%, and 232%, respectively) in the postmenopausal compared with the premenopausal women, whereas HDL-C levels were similar. Plasma TRL, IDL, and LDL-apoB-100 levels and pool sizes (PS) were significantly higher in the postmenopausal than premenopausal women. These differences were accounted for by lower TRL, IDL, and LDL apoB-100 FCR ( P r =−0.46; P r =0.62; P r =−0.70; P Conclusions— The mechanism for the increase in TRL and LDL apoB-100 PS observed in the postmenopausal women was determined predominantly by decreased TRL and LDL catabolism rather than increased production. No differences were observed in HDL apoA-I kinetics between groups. |
| Databáze: | OpenAIRE |
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