Endometrial microcalcifications detected by ultrasonography: clinical associations, histopathology, and potential etiology
| Autor: | Curtis Duffield, Alexander M. Truskinovsky, Eugenio O. Gerscovich, Philip J. Vogt |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
medicine.medical_specialty Pathology Psammoma body medicine.medical_treatment Endometrium Malignancy Pathology and Forensic Medicine Polyps Endometrial Polyp Carcinoma Medicine Humans Vaginal bleeding Aged Ultrasonography Aged 80 and over Uterine Diseases business.industry Age Factors Obstetrics and Gynecology Calcinosis Hormone replacement therapy (menopause) Middle Aged medicine.disease Endometrial Neoplasms Postmenopause medicine.anatomical_structure Histopathology Female medicine.symptom business Carcinoma Endometrioid |
| Zdroj: | International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 27(1) |
| ISSN: | 0277-1691 |
| Popis: | Endometrial microcalcifications are uncommon, with alleged clinical implications ranging from innocuous to ominous. We reviewed the histopathologic slides from 29 patients who had endometrial echogenic foci on pelvic ultrasound and found many endometrial microcalcifications. The extent of microcalcifications in each specimen was graded on a semiquantitative scale from 0 to 3. The mean patient age was 54 years (range, 34-81 years). The specimens included endometrial biopsies, curettages, and hysterectomies. Most of the patients had presented with abnormal vaginal bleeding. Fifteen patients (51.7%) were postmenopausal, 10 (34.5%) were premenopausal, and the rest were perimenopausal. The most frequent endometrial types were atrophic (39.5%), inactive (23.3%), and proliferative (14%). Six specimens (14%) showed benign endometrial polyps. One patient had well-differentiated endometrioid carcinoma of the endometrium without myometrial invasion. Specimens from 16 patients (55.2%) had microcalcifications. The patients with calcifications were older than those without calcifications (mean age, 60 vs. 47 years, respectively; P = 0.017). The extent of microcalcifications positively correlated with the presence of endometrial polyps (P = 0.00076), postmenopausal state (P = 0.004), atrophic endometrium (P = 0.002), and hormone replacement therapy (P = 0.013). The microcalcifications were concentric or amorphous, intraglandular or stromal. They were focally associated with minute papillary epithelial projections or with degenerated endometrial glands. Follow-up was available on 26 patients (89.7%). Except for the patient with endometrioid carcinoma, none has developed uterine, adnexal, or peritoneal malignancy. In summary, endometrial microcalcifications are histologically heterogeneous and are associated with older patient age, postmenopausal state, atrophic endometrium, and endometrial polyps. Those found incidentally by means of pelvic ultrasonography, in our experience, did not portend malignancy. |
| Databáze: | OpenAIRE |
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