Acipimox during exercise points to an inhibitory feedback of GH on ghrelin secretion in bulimic and healthy women
| Autor: | Martin Hill, Jara Nedvidkova, Hana Papezova, Karel Vondra, Kvido Smitka, Vojtech Hainer |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Glycerol Acipimox medicine.medical_specialty Pituitary gland Physiology Clinical Biochemistry Physical exercise Fatty Acids Nonesterified Biochemistry Body Mass Index Cellular and Molecular Neuroscience Endocrinology Internal medicine medicine Humans Neuropeptide Y Bulimia Nervosa Exercise Hypolipidemic Agents Feedback Physiological Human Growth Hormone Chemistry Stomach digestive oral and skin physiology Neuropeptide Y receptor Ghrelin Human Experimentation medicine.anatomical_structure Gastric Mucosa Case-Control Studies Pituitary Gland Pyrazines Lean body mass Female hormones hormone substitutes and hormone antagonists Ghrelin secretion medicine.drug |
| Zdroj: | Regulatory Peptides. 167:134-139 |
| ISSN: | 0167-0115 |
| Popis: | Objective Ghrelin is predominantly produced by the stomach and the growth hormone (GH)-ghrelin feedback loop between the stomach and the pituitary gland has recently been suggested. The disruption of the gut-brain axis might be involved in bulimia nervosa (BN). Methods We investigated responses of plasma GH, ghrelin, and neuropeptide Y (NPY) concentrations to exercise or to exercise after the administration of the antilipolytic drug Acipimox (Aci) in seven BN patients and seven healthy women (C). Aci was administered 1 h before exercise (45 min, 2 W/kg of lean body mass/LBM/). Ghrelin, GH, NPY, free fatty acids (FFA) and glycerol plasma levels were measured during the test using commercial kits. Results The exercise induced an increase in plasma GH, NPY and FFA in both groups and a decrease in plasma ghrelin levels only in BN patients. Exercise after Aci administration resulted in an increase in plasma GH, and a decrease in plasma ghrelin in both groups; NPY increased more in BN patients. Exercise-induced FFA increase was depressed after Aci. Conclusions We conclude that the Aci-induced suppression in plasma ghrelin levels during exercise in both groups suggests a negative feedback of GH on ghrelin secretion. Observed changes in plasma FFA levels were not related to changes in GH and ghrelin levels. |
| Databáze: | OpenAIRE |
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