Carcinoma-like signet-ring cells in gastric mucosa-associated lymphoid tissue (MALT) lymphoma
| Autor: | Franco Bonetti, Aldo Scarpa, Gian Mario Mariuzzi, Giuseppe Zamboni, Fabio Menestrina, G. Franzin, Maurizio Pea |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Biopsy Adult Aged Biopsy Carcinoma Signet Ring Cell/*pathology/surgery Case Report Female Follow-Up Studies Gastroscopy Human Lymphoma Mucosa-Associated Lymphoid Tissue/*pathology/surgery Pathology and Forensic Medicine Neoplasms Multiple Primary Stomach Neoplasms immune system diseases hemic and lymphatic diseases Gastroscopy medicine Gastric mucosa Carcinoma Humans Aged Lamina propria Signet ring cell business.industry MALT lymphoma Lymphoma B-Cell Marginal Zone Middle Aged medicine.disease digestive system diseases Lymphoma Foveolar cell medicine.anatomical_structure Adenocarcinoma Female Surgery Anatomy business Carcinoma Signet Ring Cell Follow-Up Studies |
| Popis: | We noticed the presence of epithelial signet-ring cells (SRCs) in a proportion of primary gastric B-cell lymphomas, and in some endoscopic biopsies we found it difficult to decide whether they represented an associated carcinoma. To evaluate the frequency and nature of this phenomenon, we reviewed 108 stomachs resected for primary lymphoma, including 70 mucosa-associated lymphoid tissue (MALT) and 38 non-MALT lymphomas. We found SRCs, either isolated or grouped in clusters, in 26 of 70 MALT lymphomas. The SRCs were always localized in the superficial portion of the lamina propria and associated exclusively with lymphomatous areas. Isolated and scarce SRCs were also found in four of 22 cases of polyclonal atypical lymphoid hyperplasia. Our data suggests that SRCs occurring in gastric MALT lymphomas represent a particular type of LEL in which the foveolar cells disaggregated by the lymphomatous infiltration acquire a globoid, signet-ring appearance. These "foveolar" LELs are found in 37% of MALT lymphomas and are usually associated with the more classic and constant "neck" LELs, which are localized between the foveolae and mucopeptic glands. An awareness of the existence of the foveolar LEL may help avoid overdiagnosis of SRC carcinoma on gastric endoscopic biopsies. |
| Databáze: | OpenAIRE |
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