Skin sensitization
| Autor: | John McFadden, Ian R. White, D. A. Basketter, Ian Kimber |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Pathology business.industry Local lymph node assay Health Toxicology and Mutagenesis In vitro toxicology Context (language use) General Medicine Disease Allergens Hazard analysis Toxicology medicine.disease Risk Assessment Occupational safety and health Dermatitis Allergic Contact Toxicity Tests Irritants Animals Humans Medicine business Risk assessment Intensive care medicine Allergic contact dermatitis |
| Zdroj: | Human & Experimental Toxicology. 34:1222-1230 |
| ISSN: | 1477-0903 0960-3271 |
| DOI: | 10.1177/0960327115601760 |
| Popis: | Skin sensitization associated with allergic contact dermatitis is a common health problem and is an important consideration for toxicologists in safety assessment. Historically, in vivo predictive tests have been used with good success to identify substances that have the potential to induce skin sensitization, and these tests formed the basis of safety evaluation. These original tests are now being replaced gradually either by in vitro assays or by further refinements of in vivo methods such as the local lymph node assay. Human data have also been available to inform classification decisions for some substances and have been used by risk managers to introduce measures for exposure reduction. However, humans encounter hazards in the context of exposure rather than in the form of intrinsic hazards per se, and so in this article, we have examined critically the extent to which human data have been used to refine classification decisions and safety evaluations. We have also evaluated information on the burden of human allergic skin disease and used this to address the question of whether, and to what extent, the identification and evaluation of skin sensitization hazards has led to an improvement of public and/or occupational health. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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