Connexin Implication in the Control of the Murine Beta-Cell Mass

Autor: Paolo Meda, Anne Charollais, Philippe Klee, Dorothée Caille, Jacques-Antoine Haefliger, Smaragda Lamprianou, Rossella Sarro, Manon Cederroth
Rok vydání: 2011
Předmět:
medicine.medical_specialty
Insulin/metabolism
medicine.medical_treatment
Radioimmunoassay
Fluorescent Antibody Technique
Growth Hormone/metabolism
Connexin
Connexins/genetics/metabolism
Mice
Transgenic
030209 endocrinology & metabolism
Biology
Connexins
Statistics
Nonparametric
Diabetes Mellitus/metabolism
Mice
03 medical and health sciences
0302 clinical medicine
Insulin-Secreting Cells
Diabetes mellitus
Internal medicine
Diabetes Mellitus
medicine
Insulin
Animals
ddc:612
Crosses
Genetic
Cell Size
030304 developmental biology
0303 health sciences
Type 1 diabetes
geography
geography.geographical_feature_category
medicine.disease
Islet
Mice
Inbred C57BL
Gestational diabetes
Endocrinology
Connexin 43/genetics/metabolism
Connexin 43
Growth Hormone
Pediatrics
Perinatology and Child Health
Insulin-Secreting Cells/cytology/metabolism
Beta cell
Hormone
Zdroj: Pediatric Research; Vol 70
Pediatric Research, Vol. 70, No 2 (2011) pp. 142-7
Pediatric research
Pediatric Research
ISSN: 1530-0447
0031-3998
DOI: 10.1203/pdr.0b013e318220f106
Popis: Diabetes develops when the insulin needs of peripheral cells exceed the availability or action of the hormone. This situation results from the death of most beta-cells in type 1 diabetes, and from an inability of the beta-cell mass to adapt to increasing insulin needs in type 2 and gestational diabetes. We analyzed several lines of transgenic mice and showed that connexins (Cxs), the transmembrane proteins that form gap junctions, are implicated in the modulation of the beta-cell mass. Specifically, we found that the native Cx36 does not alter islet size or insulin content, whereas the Cx43 isoform increases both parameters, and Cx32 has a similar effect only when combined with GH. These findings open interesting perspectives for the in vitro and in vivo regulation of the beta-cell mass.
Databáze: OpenAIRE
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