Synthesis of Patient-Specific Nanomaterials
| Autor: | Julie Audet, Mayra Cruz Tleugabulova, Bo Tang, Anthony J. Tavares, Warren C. W. Chan, Wayne Ngo, Jonathan R. Krieger, Yih Yang Chen, Stefan Wilhelm, Thierry Mallevaey, James Lazarovits, Fayi Song, Qiaochu Lin, Yi-Nan Zhang |
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| Rok vydání: | 2018 |
| Předmět: |
Polymers
Nanoparticle Metal Nanoparticles Bioengineering Nanotechnology Protein Corona 02 engineering and technology Nanomaterials In vivo Humans General Materials Science Particle Size Precision Medicine Chemistry Mechanical Engineering Proteins General Chemistry Patient specific 021001 nanoscience & nanotechnology Condensed Matter Physics Acquired immune system Carbon 3. Good health Nanostructures Colloidal gold Gold 0210 nano-technology Macromolecule |
| Zdroj: | Nano letters. 19(1) |
| ISSN: | 1530-6992 |
| Popis: | Nanoparticles are engineered from materials such as metals, polymers, and different carbon allotropes that do not exist within the body. Exposure to these exogenous compounds raises concerns surrounding toxicity, inflammation, and immune activation. These responses could potentially be mitigated by synthesizing nanoparticles directly from molecules derived from the host. However, efforts to assemble patient-derived macromolecules into structures with the same degree of size and shape tunability as their exogenous counterparts remains a significant challenge. Here we solve this problem by creating a new class of size- and shape-tunable personalized protein nanoparticles (PNP) made entirely from patient-derived proteins. PNPs are built into different sizes and shapes with the same degree of tunability as gold nanoparticles. They are biodegradable and do not activate innate or adaptive immunity following single and repeated administrations in vivo. PNPs can be further modified with specific protein cargos that remain catalytically active even after intracellular delivery in vivo. Finally, we demonstrate that PNPs created from different human patients have unique molecular fingerprints encoded directly into the structure of the nanoparticle. This new class of personalized nanomaterial has the potential to revolutionize how we treat patients and can become an integral component in the diagnostic and therapeutic toolbox. |
| Databáze: | OpenAIRE |
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