Preparation, physicochemical characterization and pharmacokinetics of paeoniflorin-phospholipid complex

Autor:	Lufeng Hong, Guoxi Li, Jiajia Qian, Caiyun Zhang, Weidong Chen, Weiye Cheng
Rok vydání:	2019
Předmět:	Male 0206 medical engineering Biomedical Engineering Administration Oral Infrared spectroscopy 02 engineering and technology Paeonia Rats Sprague-Dawley Biomaterials chemistry.chemical_compound Differential scanning calorimetry Glucosides 0202 electrical engineering electronic engineering information engineering Animals Fourier transform infrared spectroscopy Phospholipids Drug Carriers Hydrogen bond Anti-Inflammatory Agents Non-Steroidal General Medicine Paeoniflorin 020601 biomedical engineering Bioavailability Partition coefficient chemistry Area Under Curve Lipophilicity Monoterpenes Female 020201 artificial intelligence & image processing Nuclear chemistry
Zdroj:	Bio-Medical Materials and Engineering. 30:11-22
ISSN:	1878-3619 0959-2989
DOI:	10.3233/bme-181029
Popis:	In order to enhance lipophilicity and oral bioavailability of paeoniflorin (PF), this study developed paeoniflorin-phospholipid complex (PF-PLC) by solvent-evaporation method. The optimum preparation technology of PF-PLC was screened by the combination of single factor and orthogonal experiment. The physicochemical properties of PF-PLC were evaluated via differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD) and oil-water partition coefficient study (lgP). The result of FTIR spectra indicated that there was some strong hydrogen bond interaction and good compatibility between the phospholipid molecule and PF in the complex. DSC and XRD structure analysis showed that PF was in form of amorphous structure in PF-PLC, and lgP of PF-PLC was enhanced, suggesting that the lipophilicity of PF-PLC was higher than that of PF. In vitro release of PF-PLC showed slower release than PF solution with its cumulative release rate of 93.81% at 24 h compared to 93.43% of PF at 1.5 h. In pharmacokinetic experiments, the AUC and Cmax of the PF-PLC were 1.97-fold and 2.5-fold higher than PF solution. These results suggested that PF-PLC could enhance lipophilicity and oral bioavailability of PF and provide a promising delivery system for the application of PF.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee9f8ec753c3d2760194226c142a313 https://doi.org/10.3233/bme-181029 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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