The experience of a referral centre and literature overview of GIST and carcinoid tumours in inflammatory bowel diseases
| Autor: | Rosa Marcellinaro, Silvestro Canonico, Gianluca Pellino, Gabriele Riegler, Francesco Selvaggi, Guido Sciaudone, Giuseppe Santangelo, Severo Campione, G. Serena De Fatico, Alfonso Reginelli, Elia Guadagno, Giuseppe Candilio |
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| Přispěvatelé: | Pellino, Gianluca, Marcellinaro, Rosa, Candilio, Giuseppe, De Fatico, G. Serena, Guadagno, Elia, Campione, Severo, Santangelo, Giuseppe, Reginelli, Alfonso, Sciaudone, Guido, Riegler, Gabriele, Canonico, Silvestro, Selvaggi, Francesco, Pellino, G., Marcellinaro, R., Candilio, G., De Fatico, G. S., Guadagno, E., Campione, S., Santangelo, G., Reginelli, A., Sciaudone, G., Riegler, G., Canonico, S., Selvaggi, F. |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Crohn’s disease Disease Gastroenterology Hospitals University 0302 clinical medicine Crohn Disease Risk Factors Neuroendocrine tumour Gastrointestinal Stromal Tumor Carcinoid tumour Gastrointestinal Neoplasms Crohn's disease education.field_of_study Gastrointestinal tract GiST Incidence General Medicine Ulcerative colitis Carcinoid GIST IBD Italy 030220 oncology & carcinogenesis Gastrointestinal Neoplasm 030211 gastroenterology & hepatology Female Human Adult medicine.medical_specialty Gastrointestinal Stromal Tumors Population Carcinoid Tumor 03 medical and health sciences Internal medicine medicine Humans education neoplasms Ulcerative coliti business.industry Cancer medicine.disease digestive system diseases Surgery Colitis Ulcerative business |
| Popis: | Patients suffering from Inflammatory Bowel Diseases (IBD) are at increased risk of developing cancers of the gastrointestinal tract (GI). Adenocarcinomas are the most commonly observed GI tumours in IBD, and occur through an in inflammation-driven pathway. A trend toward reduced risk of bowel cancers has been observed in IBD in recent years, presumably related to improved medical treatments. However, some cancers may be independent from active inflammation, probably originating from altered interactions between the extremely active immune system of IBD patients and environmental factors. Data concerning gastrointestinal stromal tumours (GIST) and carcinoids of the GI in IBD patients are scanty. We report our experience with these rare cancers, and provide the readers with an overview on the topic, focusing on distinguishing and peculiar features of GIST and carcinoids of the GI in IBD compared with other cancer types and with general population, and address the treatment of such challenging conditions. Available data do not support an increased risk of GIST in IBD patients, but GI carcinoids may be more commonly observed in Crohn's disease. However, the presentation of GIST and GI carcinoids is protean and does not seem to be associated with disease activity in the involved GI segment in IBD. Conversely, some evidences suggest a potential role of inflammation in sustaining GI carcinoids in IBD. Increased awareness, longer duration of disease, and improved diagnostic modalities should also be considered when evaluating the increasing trend of CaT in CD patients. Treatment of GIST and CaT is not dissimilar from that of non-IBD patients, but prompt suspicion and diagnosis are crucial to achieve optimal outcomes. |
| Databáze: | OpenAIRE |
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