Are acute sitting-induced changes in inflammation and cerebrovascular function related to impaired mood and cognition?
| Autor: | Sophie E. Carter, Andrew D. Moss, Nicola D. Hopkins, Dick H. J. Thijssen, Richard Draijer, Claire E. Stewart |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] BF Sitting Cerebral autoregulation RC1200 03 medical and health sciences 0302 clinical medicine All institutes and research themes of the Radboud University Medical Center medicine.artery Internal medicine medicine Orthopedics and Sports Medicine 030212 general & internal medicine Effects of sleep deprivation on cognitive performance business.industry Working memory Cognition Sedentary behaviour Cerebral blood flow QP Mood Middle cerebral artery Cardiology Original Article business 030217 neurology & neurosurgery |
| Zdroj: | Sport Sciences for Health, 17, 753-762 Sport Sciences for Health, 17, 3, pp. 753-762 Sport Sciences for Health |
| ISSN: | 1824-7490 |
| Popis: | Purpose Sedentary behaviour is negatively associated with mood and cognition, yet how acute sitting contributes to these overall associations is unknown. Since sitting heightens inflammation and impairs cerebrovascular function, this study investigated the hypothesis that these sitting-induced changes are related to impaired mood and cognition. Methods Twenty-five healthy desk workers (18 male, 28.3 ± 7.5 years, BMI: 24.2 ± 3.3 kg∙m−2) were recruited. During laboratory visit one, participants were familiarised with cognitive performance tests measuring executive function, attention and working memory. During laboratory visit two, participants completed 6 h of continuous, uninterrupted sitting. At baseline and after 6 h, serum markers of inflammation, middle cerebral artery blood flow velocity (MCAv), cerebrovascular carbon dioxide reactivity (CVR), dynamic cerebral autoregulation (CA), cognitive performance and mood (positive and negative affect, alert, contented and calm) were assessed. Data were analysed using paired-samples t tests and correlation analyses. Results Following sitting, C-reactive protein (∆-1.0 µg/ml) and tissue plasminogen activator (∆-360.4 pg/ml) decreased (p −1, p = 0.012) and normalised gain increased in the very low frequency range, indicating impaired CA (∆ + 0.22%·mmHg−1, p = 0.016). Positive affect (∆-4.6, p p = 0.002) and contented (∆-7.4, p = 0.006) mood states also decreased following sitting. No significant changes in interleukin-6, tumour necrosis factor-alpha, von Willebrand factor, CVR or cognitive performance were observed (p > 0.05). The observed changes in inflammation and cerebrovascular function were not related to changes in mood (p > 0.05). Conclusion Alterations in inflammation or cerebrovascular function following six hours of prolonged, uninterrupted sitting are not related to the observed reductions in mood, indicating other mechanisms underlie the relationship between acute sitting and mood disturbances. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink