Multicentre multi-device hybrid imaging study of coronary artery disease: results from the EValuation of INtegrated Cardiac Imaging for the Detection and Characterization of Ischaemic Heart Disease (EVINCI) hybrid imaging population
| Autor: | Danilo Neglia, Valentina Lorenzoni, Rosa Poddighe, Francesco Cappelli, Arthur J.H.A. Scholte, Anna Teresinska, María Nazarena Pizzi, Riccardo Liga, Juhani Knuuti, Luis M. Rincón, Chiara Caselli, Philipp A. Kaufmann, Giancarlo Todiere, Stefano Puzzuoli, Stephen Schroeder, Jan Vontobel, Julia Stehli, Pasquale Perrone Filardi, Daniela Giannessi, Michiel A. de Graaf, Eliana Reyes, Sandy Nkomo, Selene Capitanio, Constantinos Anagnostopoulos, Alessia Gimelli, José Luis Zamorano, Covadonga Fernández-Golfín, Frank P. Graner, Dante Chiappino, Gianmario Sambuceti, Maija Mäki, Maurizio Mangione, Paolo Marraccini, Daniele Rovai, Fabio Marsico, Giuseppe Turchetti, Serafina Valente, Oliver Gaemperli, Martina Marinelli, Francesca Pugliese, Clara Carpeggiani, Massimo Lombardi, P. Marcheschi, Tanja Drosch, Santiago Aguadé-Bruix, Dominique Le Guludec, Gian Franco Gensini, François Rouzet, Mikko Pietilä, Stephan G. Nekolla, Camilla Zawaideh, S. Richard Underwood, Giancarlo Casolo, Rosa Sicari |
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| Přispěvatelé: | Liga, Riccardo, Vontobel, Jan, Rovai, Daniele, Marinelli, Martina, Caselli, Chiara, Pietila, Mikko, Teresinska, Anna, Aguadé-Bruix, Santiago, Pizzi, Maria Nazarena, Todiere, Giancarlo, Gimelli, Alessia, Chiappino, Dante, Marraccini, Paolo, Schroeder, Stephen, Drosch, Tanja, Poddighe, Rosa, Casolo, Giancarlo, Anagnostopoulos, Constantino, Pugliese, Francesca, Rouzet, Francoi, Le Guludec, Dominique, Cappelli, Francesco, Valente, Serafina, Gensini, Gian Franco, Zawaideh, Camilla, Capitanio, Selene, Sambuceti, Gianmario, Marsico, Fabio, Filardi, Pasquale Perrone, Fernández-Golfn, Covadonga, Rincón, Luis M., Graner, Frank P., De Graaf, Michiel A., Stehli, Julia, Reyes, Eliana, Nkomo, Sandy, Mäki, Maija, Lorenzoni, Valentina, Turchetti, Giuseppe, Carpeggiani, Clara, Puzzuoli, Stefano, Mangione, Maurizio, Marcheschi, Paolo, Giannessi, Daniela, Nekolla, Stephan, Lombardi, Massimo, Sicari, Rosa, Scholte, Arthur J. H. A., Zamorano, Jose L., Underwood, S. Richard, Knuuti, Juhani, Kaufmann, Philipp A., Neglia, Danilo, Gaemperli, Oliver |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Radiology Nuclear Medicine and Imaging Internationality Computed Tomography Angiography CT coronary angiography Myocardial Ischemia Fractional flow reserve Coronary Artery Disease 030204 cardiovascular system & hematology Coronary Angiography Myocardial perfusion scintigraphy Multimodal Imaging Coronary artery disease EVINCI Study Investigators 030218 nuclear medicine & medical imaging Cohort Studies Computer-Assisted 0302 clinical medicine Retrospective Studie Tomography Cardiac imaging health care economics and organizations Computed tomography angiography Observer Variation education.field_of_study medicine.diagnostic_test Statistics Myocardial Perfusion Imaging General Medicine Middle Aged Fractional Flow Reserve 3. Good health Europe Fractional Flow Reserve Myocardial medicine.anatomical_structure Cardiology Female Radiology Cardiology and Cardiovascular Medicine Human medicine.medical_specialty Population Sensitivity and Specificity Hybrid imaging Aged Humans Positron-Emission Tomography Retrospective Studies Statistics Nonparametric Tomography Emission-Computed Single-Photon Image Interpretation Computer-Assisted 03 medical and health sciences Myocardial perfusion imaging Internal medicine medicine Medical imaging Myocardial Nonparametric education Image Interpretation business.industry Original Articles ta3121 medicine.disease Coronary arteries Emission-Computed Cohort Studie business Single-Photon |
| Zdroj: | Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid European Heart Journal-Cardiovascular Imaging, 17(9), 951-960 |
| DOI: | 10.1093/ehjci/jew038 |
| Popis: | Aims Hybrid imaging provides a non-invasive assessment of coronary anatomy and myocardial perfusion. We sought to evaluate the added clinical value of hybrid imaging in a multi-centre multi-vendor setting. Methods and results Fourteen centres enrolled 252 patients with stable angina and intermediate (20-90%) pre-test likelihood of coronary artery disease (CAD) who underwent myocardial perfusion scintigraphy (MPS), CT coronary angiography (CTCA), and quantitative coronary angiography (QCA) with fractional flow reserve (FFR). Hybrid MPS/CTCA images were obtained by 3D image fusion. Blinded core-lab analyses were performed for CTCA, MPS, QCA and hybrid datasets. Hemodynamically significant CAD was ruled-in non-invasively in the presence of a matched finding (myocardial perfusion defect colocalized with stenosed coronary artery) and ruled-out with normal findings (both CTCA and MPS normal). Overall prevalence of significant CAD on QCA (.70% stenosis or 30-70% with FFR≤0.80) was 37%. Of 1004 pathological myocardial segments on MPS, 246 (25%) were reclassified from their standard coronary distribution to another territory by hybrid imaging. In this respect, in 45/252 (18%) patients, hybrid imaging reassigned an entire perfusion defect to another coronary territory, changing the final diagnosis in 42% of the cases. Hybrid imaging allowed non-invasive CAD rule-out in 41%, and rule-in in 24% of patients, with a negative and positive predictive value of 88% and 87%, respectively. Conclusion In patients at intermediate risk of CAD, hybrid imaging allows non-invasive co-localization of myocardial perfusion defects and subtending coronary arteries, impacting clinical decision-making in almost one every five subjects. ------------------------------------------------------------------------------------------------------------------------------- |
| Databáze: | OpenAIRE |
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