Obesity and Circulating Levels of Vitamin D before and after Weight Loss Induced by a Very Low-Calorie Ketogenic Diet
| Autor: | Cristiana Randazzo, Antonio Maria Borzì, Sabina Gurrera, Francesco Meli, Giuseppe Rosafio, Rosalia Caldarella, Silvio Buscemi, Carola Buscemi, Salvatore Milazzo, Davide Corleo, Giovanni De Pergola, Marcello Ciaccio, Anna Maria Barile, Valentina Settipani |
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| Přispěvatelé: | Buscemi, Silvio, Buscemi, Carola, Corleo, Davide, De Pergola, Giovanni, Caldarella, Rosalia, Meli, Francesco, Randazzo, Cristiana, Milazzo, Salvatore, Barile, Anna Maria, Rosafio, Giuseppe, Settipani, Valentina, Gurrera, Sabina, Borzì, Antonio Maria, Ciaccio, Marcello |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty obesity medicine.medical_treatment vitamin D chemistry.chemical_element Adipose tissue Calcium Article Phosphorus metabolism Cohort Studies parathormone Weight loss Internal medicine Weight Loss Vitamin D and neurology Humans Medicine TX341-641 Settore MED/49 - Scienze Tecniche Dietetiche Applicate Nutrition and Dietetics Nutrition. Foods and food supply business.industry fat mass Middle Aged medicine.disease Obesity Endocrinology Adipose Tissue chemistry Parathyroid Hormone ketogenic diet fat ma Female medicine.symptom Diet Ketogenic business Body mass index Food Science Ketogenic diet |
| Zdroj: | Nutrients Volume 13 Issue 6 Nutrients, Vol 13, Iss 1829, p 1829 (2021) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13061829 |
| Popis: | Background: Vitamin D plays a pivotal role in calcium and phosphorus metabolism, also influencing bone tissue. Several studies have reported that vitamin D blood levels were significantly lower in people with obesity, probably due to its uptake by the adipose tissue. Clinical studies that investigated the changes of circulating levels of vitamin D following weight loss reported controversial data. A very low-calorie ketogenic diet is acknowledged as a reliable treatment to achieve a rapid weight loss. Therefore, we investigated the effect of weight loss, consequent to a very low-calorie ketogenic diet, on vitamin D blood concentrations. Methods: A cohort of 31 people with obesity underwent a very low-calorie ketogenic diet for 10–12 weeks. The serum concentrations of vitamin D, parathormone, calcium and phosphorous were measured before and after weight loss they were compared to a control group of 20 non-obese, non-diabetic, age- and gender-matched persons. Results: Patients with obesity had a higher habitual intake of vitamin D than the control group (p < 0.05). However, the vitamin D blood levels of the obese group were significantly lower than those of the control group (p < 0.005) and they increased after weight loss (p < 0.001). At baseline, vitamin D blood concentrations of the persons with obesity were significantly correlated with both fat mass–kg (r = −0.40 p < 0.05) and body mass index (r = −0.47 0.01). Following very low-calorie ketogenic diet, the change in vitamin D serum concentrations was correlated only with the change in fat mass–kg (r = −0.43 0.01). Conclusion: This study confirmed that patients with obesity have lower vitamin D levels that normalize after significant weight loss, supporting the hypothesis that vitamin D is stored in the adipose tissue and released following weight loss. |
| Databáze: | OpenAIRE |
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