Relationship between Intrinsically Photosensitive Ganglion Cell Function and Circadian Regulation in Diabetic Retinopathy
| Autor: | Sirimon Reutrakul, Ben S. Gerber, Jade J. Yeh, Jason C Park, Kirstie K. Danielson, J. Jason McAnany, Stephanie J. Crowley, Medha Priyadarshini, Felix Y. Chau, Tracy Baynard, Erin C. Hanlon |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Retinal Ganglion Cells medicine.medical_specialty Evening Hydrocortisone lcsh:Medicine 030209 endocrinology & metabolism Reflex Pupillary Article Melatonin 03 medical and health sciences 0302 clinical medicine Endocrinology Sleep Disorders Circadian Rhythm Internal medicine Circadian Clocks Sleep Initiation and Maintenance Disorders Insomnia medicine Pupillary response Humans Circadian rhythm Pupillary light reflex lcsh:Science Cells Cultured Aged Multidisciplinary Diabetic Retinopathy business.industry lcsh:R Intrinsically photosensitive retinal ganglion cells Endocrine system and metabolic diseases Actigraphy Middle Aged Adie Syndrome Cross-Sectional Studies Diabetes Mellitus Type 2 lcsh:Q Female medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) |
| ISSN: | 2045-2322 |
| Popis: | Background: Intrinsically photosensitive retinal ganglion cells (ipRGCs) control non-visual light responses (e.g. pupillary light reflex and circadian entrainment). Patients with diabetic retinopathy (DR) show reduced ipRGC function, as inferred by abnormalities in the post illumination pupil response (PIPR). We explored whether ipRGC function in DR is associated with circadian outputs and sleep/wake behavior. Methods: Forty-five participants (15 without diabetes, 15 with type 2 diabetes (T2D) and no DR, 15 with T2D and DR) participated. ipRGC function was inferred from the PIPR (pupil size following stimulus offset). Circadian outputs were melatonin amplitude (overnight urinary 6-sulfatoxymelatonin (aMT6s)) and timing (dim light melatonin onset (DLMO)), and evening salivary cortisol levels. Sleep/wake patterns were measured with wrist actigraphy and insomnia symptoms were assessed subjectively. Results: Patients with T2D and DR had smaller PIPR and lower urinary aMT6s than other groups (p |
| Databáze: | OpenAIRE |
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