| Autor: |
H.J.M. Gijsen, H.C.C.K. van Bakel, W. Zwaan, L.A. Hulshof |
| Přispěvatelé: |
Macromolecular and Organic Chemistry, Chemical Reactor Engineering |
| Jazyk: |
angličtina |
| Rok vydání: |
1999 |
| Předmět: |
|
| Zdroj: |
Organic Process Research & Development, 3(1), 38-43. American Chemical Society |
| ISSN: |
1083-6160 |
| Popis: |
A scaleable process for the chlorination of 5-amino-2,4,6-triiodoisophthalic acid to the corresponding acid chloride, a building block for the synthesis of iodinated X-ray contrast agents, has been developed. Two dimeric byproducts have been isolated and assigned structures consistent with an amide and an anhydride. Hydrolysis of the N-sulfinyl intermediate and simultaneous crystallisation of the phthalic acid chloride have been optimised by applying fractional factorial design. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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